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Address

Department of Analytical Chemistry,
Faculty of Pharmaceutical Science,
Toho University

Miyama2-2-1, Funabashi,
Chiba, 274-8510 Japan

Achievement

 

Publications (since 2009)

  1. Sakamoto T, Onuma R, Furukawa S, Hayasaka A, Onozato M, Nakazawa H, Iizuka H, Ichiba H, Fukushima T: Liquid chromatography-mass spectrometry with triazole-bonded stationary phase for N-methyl-D-aspartate receptor-related amino acids: Development and application in microdialysis studies. Anal Bioanal Chemin press.
  2. Onozato M, Nakazawa H, Ishimaru K, Nagashima C, Fukumoto M, Hakariya H, Sakamoto T, Ichiba H, Fukushima T: D-Serine levels in rat plasma and striatum following D-serine administration and their nicergoline-induced alterations: an in vivo microdialysis study. Heliyon. in press.
  3. Matsumoto Y, Niwa M, Mouri A, Noda Y, Fukushima T, Ozaki N, Nabeshima T: Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice. Psychopharmacol. in press.
  4. Iizuka H, Harashima T, Takahashi S, Kuwabara R, Naito Y, Sakamoto T, Onozato M, Ichiba H, Fukushima T: Chromatographic profiles of tryptophan and kynurenine enantiomers derivatized with (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole using LC-MS/MS on a triazole-bonded column. Chirality. in press.
  5. Onozato M, Ishimaru K, Nagashima C, Fukumoto M, Nakazawa H, Shishikura M, Sakamoto T, Iizuka H, Ichiba H, Fukushima T: S-Methyl-L-cysteine levels in plasma and striatum following its intraperitoneal administration and the effects on striatal D-serine levels in rats: an in vivo microdialysis study. Research & Reviews: Journal of Pharmacy and Pharmaceutical Sciences. 5: 57-63, 2016.
  6. Onozato M, Nakazawa H, Hakariya H, Shishikura M, Nagashima C, Ishimaru K, Sakamoto T, Iizuka H, Ichiba H, Fukushima T: Effect of risperidone on plasma D-serine concentration in rats post-administered with D-serine. Life Sci. 158: 98-103, 2016.
  7. Onozato M, Nishigaki A, Okoshi K: Polycyclic aromatic hydrocarbons in sediments and bivalves on the pacific coast of Japan: Influence of tsunami and fire.  PLoS One. 11(5): e0156447, 2016. 
  8. Takahashi S, Iizuka H, Kuwabara R, Naito Y, Sakamoto T, Miyagi A, Onozato M, Ichiba H, Fukushima T: Determination of L-tryptophan and L-kynurenine derivatized with (R)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole by LC-MS/MS on a triazole-bonded column and their quantification in human serum. Biomed Chromatogr. 30: 1481-1486, 2016.
  9. Sakamoto T, Kuwabara R, Takahashi S, Onozato M, Ichiba H, Iizuka H, Fukushima T: Determination of D-serine in human serum by LC-MS/MS using a triazole-bonded column after pre-column derivatization with (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylamino sulfonyl)-2,1,3-benzoxadiazole. Anal Bioanal Chem. 408: 517-526, 2016.
  10. Iwasaki M, Kashiwaguma Y, Nagashima C, Izumi M, Uekusa A, Iwasa S, Onozato M, Ichiba H, Fukushima T: A high-performance liquid chromatography assay with a triazole-bonded column for evaluation of D-amino acid oxidase activity. Biomed Chromatogr. 30: 384-389, 2016.
  11. Toriumi K, Mamiya T, Song Z,  Honjo T,  Watanabe H, Tanaka J,  Kondo M, Mouri A,  Kim HC, Nitta A, Fukushima T, Nabeshima T:Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate. Eur Neuropsychopharmacol. 25: 2108-2017, 2015. 
  12. Ichiba H, Yonei M, Sakamoto T, Kuwayama H, Hamada Y, Yamada H, Onozato M, Hiruta T, Nakagawa H, Fukushima T: Development of a selective fluorescent ligand for aluminum ion having a 6-chloro-pyridazine moiety. Inorganica Chimica Acta. 435: 53-59, 2015.
  13. Onozato M, Nishikiori M, Iizuka H, Ichiba H, Sadamoto K, Fukushima T :Determination of sex-based differences in serum γ-linoleic acid and dihomo-γ-linoleic acid using gas chromatography-mass spectrometry. J Chromatogr B. 997: 116-121, 2015.
  14. FukushimaT, Taniguchi E, Yamada H, Kato K, Shimizu A, Nishiguchi Y, Onozato M, Ichiba H, Azuma Y: Anti-proliferative effect of Fe (III) complexed with 1-(2-hydroxy-3-methoxybenzaldehyde)-4-aminosalicylhydrazone in HepG2 cells. BioMetals. 28 (4): 669-677, 2015.
  15. Fukushima T, Sugiura A, Furuta I, Iwasa S, Iizuka H, Ichiba H, Onozato M, Hikawa H, Yokoyama Y: Enantiomeric separation of monosubstituted tryptophan derivatives and metabolites by HPLC with aCinchona alkaloid-based zwitterionic chiral stationary phase and its application to the evaluation of the optical purity of synthesized 6-chloro-L-tryptophan.  Int J Tryptophan Res. 8: 1-5, 2015.
  16. Nishikiori M, Iizuka H, Ichiba H, Sadamoto K, Fukushima T:Determination of free fatty acids in human serum by HPLC with fluorescence detection.  J Chromatogr Sci. 53(4): 537-541, 2015.
  17. Fukushima T, Iizuka H, Yokota A, Suzuki T, Ohno C, Kono Y, Nishikiori M, Seki A, Ichiba H, Watanabe Y, Hongo S, Utsunomiya M, Nakatani M, Sadamoto K, Yoshio T: Quantitative analyses of schizophrenia-associated metabolites in serum: Serum D-lactate levels are negatively correlated with gamma-glutamylcysteine in medicated schizophrenia patients.  PLoS One. e101652, 2014.
  18. Shishikura M, Hakariya H,  Iwasa S, Yoshio T, Ichiba H, Yorita K, Fukui K, Fukushima T: Evaluation of human D-amino acid oxidase inhibition by anti-psychotic drugs in vitroBiosci Trends. 8(3): 149-154, 2014.
  19. Kono Y, Iizuka H, Isokawa M, Tsunoda M, Ichiba H, Sadamoto K, Fukushima T: HPLC-fluorescence determination of thiol compounds in the serum of human male and female subjects using HILIC-mode column. Biomed Chromatogr28(5): 589-593, 2014.
  20. Owada Y, Takahashi M, Iwasa S, Ichiba H, Sadamoto K, Fukushima T: Enantiomeric separation of tolperisone and eperisone by reversed-phase HPLC with cellulose tris(3-chloro-4-methylphenylcarbamate)-coated chiral column.  Biomed Chromatogr. 28(1): 102-105, 2014.
  21. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence.  Int J Neuropsychopharmacol. 17(3): 443-453, 2014.
  22. Nishiguchi Y, Kitamura K, Watanabe N, Kozaki A, Otani H, Ohashi H, Kume M, Haruta N, Iwasa S, Fukushima T: An improved quantitative real-time PCR protocol for precisely measuring D-amino acid oxidase mRNA in rat tissues. Int J Anal Bio-Sci. 1(1): 37-44, 2013.
  23. Iizuka H, Watanabe S, Koshikawa M, Matsumoto Y, Aoyama Y, Ichiba H, Nabeshima T, Fukushima T: Decreased L-tryptophan concentration in distinctive brain regions of mice treated repeatedly with phencyclidine. Anal Bioanal Chem. 405: 8137-8141, 2013.
  24. Ohashi H, Iizuka H, Yoshihara S, Otani H, Kume M, Sadamoto K, Ichiba H, Fukushima T: Determination of L-tryptophan and L-kynurenine in human serum by using LC-MS after derivatization with (R)-DBD-PyNCS. Int J Tryptophan Res. 6: 9-14, 2013.
  25. Kozaki A, Iwasa S, Hosoda S, Nishiguchi Y, Nakayama M, Ichiba H, Fukushima T:  Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate.  Biosci Trends  6(5): 241-247, 2012.
  26. Yoshihara S, Otani H, Tsunoda M, Ishii K, Iizuka H,  Ichiba H,  Fukushima T:  Alterations in extracellular tryptophan and dopamine concentrations in rat striatum following peripheral administration of D- and L-tryptophan: An in vivo microdialysis study.  Neurosci lett 526: 74-78, 2012.
  27. Ichiba H, Hanami K, Yagasaki K, Tanaka M, Ito H, Fukushima T:    A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion.  Drug Discoveries Ther. 6(1): 44-48, 2012. 
  28. Yamada H, Kojo M, Nakahara T, Murakami K, Kakima T, Ichiba H, Yajima T, Fukushima T: Development of a fluorescent chelating ligand for scandium ion having a Schiff base moiety. Spectrochim Acta Part A 90: 72-77, 2012.
  29. Haruta N, Iizuka H, Ishii K, Yoshihara S, Ichiba H, Fukushima T: Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan. Proc. Jpn. Acad. Ser. B 87: 641-648, 2011.
  30. Hsu WY, Kuo CY, Fukushima T, Imai K, Chen CM, Lin PY, Lee JA: Enantioselective determination of 3-hydroxybutyrate in the tissues of normal and streptozotocin-induced diabetic rats of different ages.  J Chromatogr B 879: 3331-3336, 2011.
  31. Iwasa S, Tabara H, Song Z, Nakabayashi M, Yokoyama Y, Fukushima T: Inhibition of D-amino acid oxidase activity by antipsychotic drugs evaluated by a fluorometric assay using D-kynurenine as substrate. Yakugaku Zasshi 131: 1111-1116, 2011.
  32. Song Z, Ge D, Ishii K, Yamada H, Toriumi K, Watanabe H, Nabeshima T, Fukushima T: Determination of N-acetylaspartic acid concentration in the mouse brain using HPLC with fluorescence detection.  Biomed Chromatogr in press.
  33. Iizuka H, Ishii K, Hirasa Y, Kubo K, Fukushima T: Fluorescence determination of D- and L-tryptophan concentrations in rat plasma following administration of tryptophan enantiomers using HPLC with pre-column derivatization.  J Chromatogr B 879: 3208-3213, 2011.
  34. Ishii K, Iizuka H, Ogaya T, Song Z, Fukushima T: Comparative study on kynurenic acid production in the rat striatum by tryptophan enantiomers: an in vivo microdialysis study. Chirality 23: E12–E15, 2011.
  35. Nakamoto M, Ishigouoka H, Sato K, Yamauchi T, Tonogi M, Yamane G, Tanaka Y, Ichiba H, Fukushima T, Inouye Y: Feasibility of bioavailability testing by simultaneous determination of serum concentrations of tegafur and 5-fluorour acil after TS-1 oral or tube administration for chemotherapy in oral cancer patients. J Health Sci 56: 684-689, 2010.
  36. Iizuka H, Hirasa Y, Kubo K, Ishii K, Toyo’oka T, Fukushima T: Enantiomeric separation of D, L-tryptophan and D, L-kynurenine by HPLC using pre-column fluorescence derivatization with R(-)-DBD-PyNCS. Biomed Chromatogr 25: 743-747, 2011.
  37. Higashi T, Ichikawa T, Inagaki S, Min JZ, Fukushima T, Toyo’oka T: Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatographyelectrospray ionization-tandem mass spectrometry. J Pharm Biomed Anal 52: 809818, 2010.

  38. Yamada H, Shirai A, Kato K, Kimura J, Ichiba H, Yajima T, Fukushima T: Development of a quinazoline-based chelating ligand for zinc ion and its application to validation of a zinc-ion-coordinated compound. Chem Pharm Bull 58: 875-878, 2010.
  39. Song Z, Ogaya T, Ishii K, Ichiba H, Iizuka H, Fukushima T: Utilization of kynurenic acid produced from d-kynurenine in an in vitro assay of d-amino acid oxidase activity. J Health Sci 56: 341-346, 2010.
  40. Ishii K, Ogaya T, Song Z, Iizuka H, Fukushima T: Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers. Chirality 22: 901-906, 2010.
  41. Ichiba H, Nakamoto M, Yajima T, Takayama M, Fukushima T: Analysis of oxidation process of cholecystokinin octapeptide with reactive oxygen species by high-performance liquid chromatography and subsequent electrospray ionization mass spectrometry. Biomed Chromatogr 24: 140-147, 2010
  42. Iizuka H, Obata K, Yajima T, Ichiba H, Fukushima T: Development of a fluorimetric detection method for cinnabarinic acid using ortho-tolyl hydrazine as the derivatization reagent. Biomed Chromatogr 24: 231-234, 2010
  43. Sasaki T, Fukushima T, Yamashita K, Toyo'oka T: Stereoselective effect of kynurenine enantiomers on the excretion of serotonin and its metabolite in rat urine. Chirality 22: 258-261, 2010
  44. Tomiya M, Fukushima T, Ogaya T, Sone Y, Mitsuhashi S, Toyo'oka T: Determination of kynurenic acid levels in rat brain microdialysis samples and changes in kynurenic acid levels induced by N-acetylaspartic acid. Biomed Chromatogr in press
  45. Ogaya T, Song Z, Ishii K, Fukushima T: Changes in extracellular kynurenic acid concentrations in rat prefrontal cortex after D-kynurenine infusion: An in vivo microdialysis study. Neurochem Res 35, 559-563, 2010
  46. Ichiba H, Ogawa T, Yajima T, Fukushima T: Analysis of hydroxyl radical-induced oxidation process of glucagon by reversed-phase HPLC and ESI-MS/MS. Biomed Chromatogr 23: 1051-1058, 2009
  47. Ichiba H, Nakamoto M, Yajima T, Fukushima T: In Vitro Binding Assay of 31Methionine-oxidized Cholesystokinin Octapeptide to the CCKB Receptor. J Health Sci 55: 636-640, 2009
  48. Iwasa S, Enomoto A, Onoue S, Nakai M, Yajima T, Fukushima T: Chromatographic Analysis of Conformationally Changed Insulin and Its Cytotoxic Effect on PC12 Cells. J Health Sci 55: 825-831, 2009
  49. Fukushima T, Sone Y, Mitsuhashi S, Tomiya M, Toyo'oka T: Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomers. Chirality 21 : 468-472, 2009
  50. Yamashita K, Fukushima T, Sasaki T, Arai K, Toyo'oka T: Enantiomeric separation of D- and L-serine using high-performance liquid chromatography with electrochemical detection following pre-column diastereomer derivatization. Biomed Chromatogr 23 : 793-797, 2009
  51. Kimura J, Yamada H, Ogura H, Yajima T, Fukushima T: Development of a fluorescent chelating ligand for gallium ion having a quinazoline structure with two Schiff base moieties. Anal Chim Acta 635: 207-213, 2009
  52. Kimura J, Yamada H, Yajima T, Fukushima T: Enhancement effect of some phosphorylated compounds on fluorescence of quinazoline-based chelating ligand complexed with gallium ion. J Lumin 129: 1362-1365, 2009

Scientific Conference (since 2009)

  1. ◯Takeshi Fukushima, Hayato Otani, Kana Ishii, Shunsuke Yoshihara, Makoto Tsunoda, Hideaki Iizuka: Determination of tryptophan and kynurenic acid concentrations in rats after intraperitoneal administration of tryptophan enantiomers. 13th International Society for Tryptophan Research (ISTRY 2012) Sydney 2012. 11. 09
  2. Misato Kume, Hayato Ohashi, Hideaki Iizuka, Hayato Otani, Yoshikazu Nishiguchi, Hideaki Ichiba, ◯Takeshi Fukushima: Increased kynurenic acid concentration in rat plasma by repeated ketamine administration. 13th International Society for Tryptophan Research (ISTRY 2012) Sydney 2012. 11. 09
  3. ◯ Hideaki Iizuka, Mayuko Koshikawa, Misato Kume, Shoko Watanabe, Hayato Ohashi, Takeshi Fukushima: Fluorimetric determination of L-tryptophan in serum or brain homogenate of Sprague-Dawley rats by HPLC using precolumn fluorescence derivatization with R(-)-DBD-PyNCS. 13th International Society for Tryptophan Research (ISTRY 2012) Sydney 2012. 11. 08
  4. ◯ Fukushima T: Determination of neuroactive compounds by HPLC with fluorescence detection in pre-clinical and clinical researches (Keynote Lecture Ⅳ). The 7th Joint Seminar on Biomedical Sciences, Hat Yai, 2011. 10. 13, 14
  5. Haruta N, Iizuka H, Ishii K, Yoshihara S, ◯Fukushima T: Effect of repeated ketamine treatment on the plasma concentration of a DAAO-inhibitory compound, 3-methylpyrazole-5-carboxylic acid, following its administration to rats. The 7th Joint Seminar on Biomedical Sciences, Hat Yai, 2011. 10. 13, 14
  6. Takeshi Fukushima, ◯ Kana Ishii, Tadahiro Ogaya, Ziyu Song : Comparative study on the kynurenic acid production in rat between tryptophan enantiomers. 22nd International Symposium on Chirality (ISCD 2010), Sapporo, 2010, 7, 14
  7. Tadahiro Ogaya, Takeshi Fukushima, Shogo Mitsuhashi, Yukiko Sone, Masayuki Tomiya, Toshimasa Toyo’oka: In vivo metabolism of D-kynurenine to kynurenic acid in rats. The 1st International Conference of D-Amino Acid Research, Awaji, 2009. 7
  8. Takeshi Fukushima, Shogo Mitsuhashi, Masayuki Tomiya, Toshimasa Toyo’oka: Determination of plasma kynurenate and kynurenine in the ketamine-treated rats. 12th Meeting of the International Society for Tryptophan Research, Firenze, 2009. 7 
  9. Hideaki Iizuka, Kensaku Obata, Takehiko Yajima, Fukushima T: Sensitive determination of cinnabarinic acid by HPLC-fluorometric detection using ortho-tolyl hydrazine as the derivatization reagent. 12th Meeting of the International Society for Tryptophan Research. Firenze. 2009. 7
  10. Hideaki Ichiba, Mio Nakamoto, Tomoko Ogawa, Takehiko Yajima, Takeshi Fukushima: Analysis of ROS-induced oxidations of bioactive peptides by HPLC and/or mass-spectrometry. The 6th Joint Seminar on Biomedical Sciences, Tokyo, 2009. 10
  11. Takeshi Fukushima, Tadahiro Ogaya, Shogo Mitsuhashi, Yukiko Sone, Masayuki Tomiya, Toshimasa Toyo’oka: In vivo metabolism of D-kynurenine to kynurenic acid in rats. The 6th Joint Seminar on Biomedical Sciences, Tokyo, 2009. 10