研究

糖尿病・内分泌・代謝センターでは、主に糖尿病、脂質異常、肥満についての研究を行っています。また、代謝疾患は動脈硬化と密接に関係するため、Cardio-Ankle Vascular Index (CAVI)を用いて血管機能についての研究も行っています。

研究論文(2018年1月〜2020年8月)
Low serum insulin-like growth factor-1 level is a predictor of low total weight loss percentage after sleeve gastrectomy.
Ohira M, Watanabe Y, Yamaguchi T, Saiki A, Oshiro T, Tatsuno I.
Surg Obes Relat Dis. 2020; in press. https://doi.org/10.1016/j.soard.2020.07.033

Impact of Mental Health Background and Nutrition Intake on Medium-Term Weight Loss in Japanese Patients Undergoing Laparoscopic Sleeve Gastrectomy.
Saiki A, Kanai R, Nakamura S, Tanaka S, Oka R, Watanabe Y, Yamaguchi T, Ohira M, Oshiro T, Hayashi K, Tatsuno I.
Obes Facts. 2020;in press. https://doi.org/10.1159/000509342

New Horizons of Arterial Stiffness Developed Using Cardio-Ankle Vascular Index (CAVI).
Saiki A, Ohira M, Yamaguchi T, Nagayama D, Shimizu N, Shirai K, Tatsuno I.
J Atheroscler Thromb. 2020;27(8):732-748.
https://doi.org/10.5551/jat.RV17043

Fracture Risk Assessment Tool May Not Indicate Bone Fragility in Women With Type 2 Diabetes.
Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Am J Med Sci. 2020;in press. https://doi.org/10.1016/j.amjms.2020.04.002

Outcome of pitavastatin versus atorvastatin therapy in patients with hypercholesterolemia at high risk for atherosclerotic cardiovascular disease.
Moroi M, Nagayama D, Hara F, Saiki A, Shimizu K, Takahashi M, Sato N, Shiba T, Sugimoto H, Fujioka T, Chiba T, Nishizawa K, Usui S, Iwasaki Y, Tatsuno I, Sugi K, Yamasaki J, Yamamura S, Shirai K. Int J Cardiol. 2020;305:139-146. https://doi.org/10.1016/j.ijcard.2020.01.006

Marker Of Sepsis Severity Is Associated With The Variation In Cardio-Ankle Vascular Index (CAVI) During Sepsis Treatment.
Nagayama D, Imamura H, Endo K, Saiki A, Sato Y, Yamaguchi T, Watanabe Y, Ohira M, Shirai K, Tatsuno I. Vasc Health Risk Manag. 2019;15:509-516. https://doi.org/10.2147/VHRM.S228506

Background characteristics and postoperative outcomes of insufficient weight loss after laparoscopic sleeve gastrectomy in Japanese patients.
Saiki A, Yamaguchi T, Tanaka S, Sasaki A, Naitoh T, Seto Y, Matsubara H, Yokote K, Okazumi S, Ugi S, Yamamoto H, Ohta M, Ishigaki Y, Kasama K, Seki Y, Irie J, Kusakabe T, Tsujino M, Shimizu H, Shirai K, Onozaki A, Kitahara A, Hayashi K, Miyazaki Y, Masaki T, Nagayama D, Yamamura S, Tatsuno I; Japanese Survey of Morbid and Treatment‐Resistant Obesity Group (J‐SMART Group).
Ann Gastroenterol Surg. 2019;3(6):638-647.
https://doi.org/10.1002/ags3.12285

Prevention of Cardiovascular Events with Omega-3 Polyunsaturated Fatty Acids and the Mechanism Involved.
Watanabe Y, Tatsuno I. J Atheroscler Thromb. 2020;27(3):183-198.
https://doi.org/10.5551/jat.50658

Fatty acid desaturase 2 is up-regulated by the treatment with statin through geranylgeranyl pyrophosphate-dependent Rho kinase pathway in HepG2 cells.
Tanaka S, Ishihara N, Suzuki S, Watanabe Y, Nagayama D, Yamaguchi T, Ohira M, Saiki A, Tanaka T, Tatsuno I. Sci Rep. 2019;9(1):10009.
https://doi.org/10.1038/s41598-019-46461-9

Laparoscopic Sleeve Gastrectomy Significantly Increases Serum Lipoprotein Lipase Level in Obese Patients.
Ohira M, Yamaguchi T, Saiki A, Nakamura S, Tanaka S, Oka R, Watanabe Y, Sato Y, Oshiro T, Murano T, Tatsuno I. Obes Facts. 2019;12(3):357-368.
https://doi.org/10.1159/000500360

Difference in positive relation between cardio-ankle vascular index (CAVI) and each of four blood pressure indices in real-world Japanese population.
Nagayama D, Watanabe Y, Saiki A, Shirai K, Tatsuno I. J Hum Hypertens. 2019;33(3):210-217. https://doi.org/10.1038/s41371-019-0167-1

Bezafibrate Ameliorates Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Hypertriglyceridemic Patients with Type 2 Diabetes Mellitus.
Yamaguchi T, Shirai K, Nagayama D, Nakamura S, Oka R, Tanaka S, Watanabe Y, Imamura H, Sato Y, Kawana H, Ohira M, Saiki A, Shimizu N, Tatsuno I.
J Atheroscler Thromb. 2019;26(7):659-669. https://doi.org/10.5551/jat.45799

Lipid Parameters are Independently Associated with Cardio-Ankle Vascular Index (CAVI) in Healthy Japanese Subjects.
Nagayama D, Watanabe Y, Saiki A, Shirai K, Tatsuno I.
J Atheroscler Thromb. 2018;25(7):621-633. https://doi.org/10.5551/jat.42291

Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women: Chiba bone survey.
Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
Endocr J. 2018;65(2):193-202. https://doi.org/10.1507/endocrj.EJ17-0331

Successful Treatment of Rapidly Progressive Life-Threatening Esophageal Submucosal Hematoma in a Patient With van der Hoeve Syndrome.
Watanabe Y, Shimizu N, Iwakawa M, Yamaguchi T, Ban N, Kawana H, Saiki A, Sakaida E, Nakaseko C, Matsuura Y, Aotsuka N, Bujo H, Tatsuno I.
J Clin Med Res. 2018;10(2):154-157. https://doi.org/10.14740/jocmr3270w

7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy.
Watanabe Y, Yamaguchi T, Ishihara N, Nakamura S, Tanaka S, Oka R, Imamura H, Sato Y, Ban N, Kawana H, Ohira M, Shimizu N, Saiki A, Tatsuno I.
Prostaglandins Other Lipid Mediat. 2018;134:16-23.
https://doi.org/10.1016/j.prostaglandins.2017.11.002

その他は以下を参照
東邦大学 教育・研究業績データベース【医学部 医学科 内科学講座 糖尿病・代謝・内分泌学分野(佐倉)】