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Department of Analytical Chemistry,
Faculty of Pharmaceutical Science,
Toho University

Miyama2-2-1, Funabashi,
Chiba, 274-8510 Japan

Research projects in the Department of Analytical Chemistry


Research on analytical aspects of overcoming schizophrenia

We aim to develop a highly sensitive determination method for the brain neurotransmitters and neuromodulators involved in the etiology of schizophrenia.  Using these analytical methods, alterations in the concentrations of these endogenous compounds are precisely investigated in the presence of a disease using an animal model for schizophrenia.  Sampling of biological fluids such as plasma or urine and sampling of extracellular fluids by a brain microdialysis technique under living conditions are carried out.

Analyses of tryptophan metabolites in mammals

One of the essential amino acids, tryptophan, is metabolized to several pharmacologically active compounds in mammals.  It is known that these metabolites are associated with some severe psychiatric diseases and could be a biomarker for useful diagnosis.  Thus, we aim to develop a novel HPLC method with fluorescence detection for these metabolites.