原著論文

原著論文

2022年

  1. Yoshihisa Asada, Kouharu Otsuki, Miki Morooka, Li Huang, Chin-Ho Chen, Kazuo Koike, Wei Li*. "Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysanthaJournal of Natural Products (2022). DOI: 10.1021/acs.jnatprod.2c00618
  2. Di Zhou, Kouharu Otsuki, Mi Zhang, Gang Chen, Zi-Song Bai, Haotian Yu, Takashi Kikuchi, Li Huang, Chin-Ho Chen*, Wei Li*, Ning Li*. "Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis", Journal of Natural Products, 85, 1658–1664 (2022). DOI:10.1021/acs.jnatprod.1c01195
  3. Mi Zhang, Kouharu Otsuki, Shizuka Kato, Yuito Ikuma, Takashi Kikuchi, Ning Li, Kazuo Koike, Wei Li*. "A feruloylated acylglycerol isolated from Wikstroemia pilosa and its distribution in ten plants of Wikstroemia species" Journal of Natural Medicines, 76, 680–685 (2022). DOI: 10.1007/s11418-022-01621-6
  4. Di Zhou, Fengjiao Zhang, Takashi Kikuchi, Miao Yao, Kouharu Otsuki, Gang Chen, Wei Li*, Ning Li*. "Lathyrane and Jatrophane Diterpenoids from Euphorbia helioscopia Evaluated for Cytotoxicity against a Paclitaxel-Resistant A549 Human Lung Cancer Cell Line",  Journal of Natural Products, 85, 1174-1179 (2022). DOI: 10.1021/acs.jnatprod.1c01050

2021年

  1. Jia-xin Qi, Di Zhou, Wan-ru Jiang, Gang Chen, Wei Li*, Ning Li*. "Dihydrophenanthrenes from medicinal plants of Orchidaceae: A review" Chinese Herbal Medicines, 13, 480-493 (2021). DOI: 10.1016/j.chmed.2021.10.004
  2. Mi Zhang, Kouharu Otsuki, Takashi Kikuchi, Zi-Song Bai, Di Zhou, Li Huang, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Ning Li*, Kazuo Koike, Wei Li*. "LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis" Journal of Natural Products, 84, 2366-2373 (2021). DOI: 10.1021/acs.jnatprod.1c00570
  3. Kouharu Otsuki#, Mi Zhang#, Wei Li*. “Natural products against HIV latency” Acupuncture and Herbal Medicine, 1, 10-21 (2021). (#equal contribution) DOI: 10.1097/HM9.0000000000000004
  4. Kouharu Otsuki, Mi Zhang, Takashi Kikuchi, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, Ning Li*, Kazuo Koike, Wei Li*. “Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation” Journal of Natural Medicines, 75, 1058-1066 (2021). DOI: 10.1007/s11418-021-01551-9
  5. Bingyang Zhang#, Di Liu#, Wenyue Ji, Kouharu Otsuki, Koji Higai, Feng Zhao*, Wei Li*,  Kazuo Koike, Feng Qiu*. “Sacraoxides A–G, Bioactive Cembranoids from Gum Resin of Boswellia sacraFrontiers in Chemistry, 9, 649287 (2021). (#equal contribution) DOI: 10.3389/fchem.2021.649287 
  6. Weixing Huang, Liqin Ding, Nan Zhang, Wei Li*, Kazuo Koike, Feng Qiu*. “Flavonoids from Eucommia ulmoides and their in vitro hepatoprotective activities” Natural Product Research, 35, 3584-3591 (2021). DOI: 10.1080/14786419.2020.1715402

2020年以前(抜粋)

  1. Kouharu Otsuki#, Mi Zhang#, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, Ning Li*, Wei Li*, Kazuo Koike. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophyllaJournal of Natural Products, 83(12), 3584-3590 (2020). (#equal contribution) DOI: 10.1021/acs.jnatprod.0c00700
  2. Kouharu Otsuki, Wei Li*, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, Kazuo Koike. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odoraJournal of Natural Products, 83(11), 3270-3277 (2020). DOI: 10.1021/acs.jnatprod.0c00540
  3. Kouharu Otsuki, Wei Li*, Yoshihisa Asada, Chin-Ho Chen, Kuo-Hsiung Lee, Kazuo Koike. “Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odoraOrganic Letters, 22(1), 11-15 (2020). DOI: 10.1021/acs.orglett.9b03539
  4. Qingbo Liu#, Yung-Yi Cheng#, Wei Li*, Li Huang, Yoshihisa Asada, Min-Tsang Hsieh, Susan L. Morris-Natschke, Chin-Ho Chen*, Kazuo Koike*, Kuo-Hsiung Lee*. “Synthesis and structure-activity relationship correlations of gnidimacrin derivatives as potent HIV-1 inhibitors and HIV latency reversing agents “ Journal of Medicinal Chemistry, 62(15), 6958-6971 (2019). (#equal contribution) DOI: 10.1021/acs.jmedchem.9b00339
  5. Naoko Sato, Wei Li*, Hiroaki Takemoto, Mio Takeuchi, Ai Nakamura, Emi Tokura, Chie Akahane, Kanako Ueno, Kana Komatsu, Noriko Kuriyama, Toshihisa Onoda, Koji Higai, Kazuo Koike. “Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent” Journal of Natural Medicines, 73(1), 163-172 (2019). DOI: 10.1007/s11418-018-1259-x
  6. Qingbo Liu, Wei Li*, Li Huang, Yoshihisa Asada, Susan L. Morris-Natschke, Chin-Ho Chen*, Kuo-Hsiung Lee*, Kazuo Koike*. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansuiEuropean Journal of Medicinal Chemistry, 156, 618-627 (2018). DOI: 10.1016/j.ejmech.2018.07.020
  7. Jie Zhang#, Tatsunori Sasaki#, Wei Li*, Kazuya Nagata, Koji Higai, Feng Feng, Jian Wang, Maosheng Cheng, Kazuo Koike. “Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princepsBioorganic & Medicinal Chemistry Letters, 28, 1194-1197 (2018). (#equal contribution) DOI: 10.1016/j.bmcl.2018.02.052
  8. Qingbo Liu, Wei Li*, Kazuya Nagata, Hongwei Fu*, Shunpei Okada, Ikumi Tanabe, Yumi Kobori, Higai Koji, Wada Norie, Tatsunori Sasaki, Yoshihisa Asada, Huanxin Zhao, Hong Bai, Kazuo Koike. “Isolation, structural elucidation, and liquid chromatography–mass spectrometry analysis of steroidal glycosides from Polygonatum odoratumJournal of Agricultural and Food Chemistry, 66, 521-531 (2018). DOI: 10.1021/acs.jafc.7b04488
  9. Wei Li*, Chao Huang, Qingbo Liu, Kazuo Koike. “Bistinospinosides A and B, dimeric clerodane diterpene glycosides from Tinospora sagittateJournal of Natural products, 80(9), 2478-2483 (2017). DOI: 10.1021/acs.jnatprod.7b00324
  10. Naoko Sato, Wei Li*, Masato Tsubaki, Koji Higai, Miho Takemoto, Tatsunori Sasaki, Toshihisa Onoda, Toshie Suzuki, Kazuo Koike. “Flavonoid glycosides from Japanese Camellia oil cakes and their inhibitory activity against advanced glycation end-products formation” Journal of Functional Foods, 35, 159-165 (2017). DOI: 10.1016/j.jff.2017.05.043
  11. Nobuyuki Takahashi, Wei Li*, Kazuo Koike. “Oleanane-type triterpenoid saponins from Silene armeriaPhytochemistry, 129, 77-85 (2016). DOI: 10.1016/j.phytochem.2016.07.011
  12. Toshihisa Onoda, Wei Li*, Tatsunori Sasaki, Megumi Miyake, Koji Higai, Kazuo Koike. “Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan” Journal of Ethnopharmacology, 186(20), 84-90 (2016). DOI: 10.1016/j.jep.2016.03.063
  13. Xinzhu Kuang, Wei Li*, Yuichiro Kanno, Naoya Yamashita, Shoko Kikkawa, Isao Azumaya, Kiyomitsu Nemoto, Yoshihisa Asada, Kazuo Koike. “Euphorins A-H, bioactive diterpenoids from Euphorbia fischerianaJournal of Natural Medicines, 70(3), 412-422 (2016). DOI: 10.1007/s11418-016-0987-z
  14. Xingzhu Kuang, Wei Li*, Yuichiro Kanno, Naoya Yamashita, Kiyomitsu Nemoto, Yoshihisa Asada, Kazuo Koike. “ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells” Journal of Natural Medicines, 70, 120-126 (2016). DOI: 10.1007/s11418-015-0940-6
  15. Weihong Lai, Li Huang, Lei Zhu, Guido Ferrari, Cliburn Chan, Wei Li*, Kuo-Hsiung Lee*, Chin-Ho Chen*. “Gnidimacrin, the potent anti-HIV diterpene can eliminate latent HIV-1 Ex Vivo by activation of PKC Beta” Journal of Medicinal Chemistry, 58, 8638-8646 (2015). DOI: 10.1021/acs.jmedchem.5b01233
  16. Tatsunori Sasaki, Wei Li*, Koji Higai, Kazuo Koike. “Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors” Bioorganic & Medicinal Chemistry Letters, 25, 1979-1981 (2015). DOI: 10.1016/j.bmcl.2015.03.014
  17. Ling Ma, Wei Li, Hanqing Wang, Xinzhu Kuang, Yanghua Liu, Qin Li, Yinghua Wang, Peng Xie, Kazuo Koike. “A simple and rapid method to identify and quantitatively analyze triterpenoid saponins in Ardisia crenata using ultrafast liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry” Journal of Pharmaceutical and Biomedical Analysis, 102, 400-408 (2015). DOI: 10.1016/j.jpba.2014.10.013
  18. Xingzhu Kuang, Wei Li*, Yuichiro Kanno, Michiru Mochizuki, Yoshio Inoue, Kazuo Koike. “Cycloartane-type triterpenes from Euphorbia fischeriana stimulate human CYP3A4 promoter activity” Bioorganic & Medicinal Chemistry Letters, 24, 5423-5427 (2014). DOI: 10.1016/j.bmcl.2014.10.032
  19. Toshihisa Onoda, Wei Li*, Koji Higai, Kazuo Koike. “Evaluation of 147 Kampo Prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents” BMC Complementary and Alternative Medicine, 14, 64 (2014). DOI: 10.1186/1472-6882-14-64
  20. Wei Li*, Songpei Li, Koji Higai, Tatsunori Sasaki, Yoshihisa Asada, Shigeru Ohshima, Kazuo Koike. “Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors” Bioorganic & Medicinal Chemistry Letters, 23, 5836-5839 (2013). DOI: 10.1016/j.bmcl.2013.08.102
  21. Tatsunori Sasaki, Wei Li*, Shinnosuke Zaike, Yoshihisa Asada, Qin Li, Fenghua Ma, Qingbo Zhang, Kazuo Koike. “Antioxidant lignoids from leaves of Ribes nigrumPhytochemistry, 95, 333-340 (2013). DOI: 10.1016/j.phytochem.2013.07.022
  22. Yoshihisa Asada*, Aya Sukemori, Takashi Watanabe, Kuber J. Malla, Takafumi Yoshikawa, Wei Li*, Xinzhu Kuang, Kazuo Koike, Chin-Ho Chen, Toshiyuki Akiyama, Keduo Qian, Kyoko Nakagawa-Goto, Susan L. Morris-Natschke, Yan Lu, Kuo-Hsiung Lee*. “Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasmeJournal of Natural Products, 76, 852-857 (2013). DOI: 10.1021/np300815t
  23. Chao Huang, Wei Li*, Fenghua Ma, Qin Li, Yoshihisa Asada, Kazuo Koike. “Tinospinosides D, E, and tinospin E, further clerodane diterpenoids from Tinospora sagittateChemical & Pharmaceutical Bulletin, 60(10), 1324-1328 (2012). DOI: 10.1248/cpb.c12-00482
  24. Wei Li*, Chao Huang, Songpei Li, Fenghua Ma, Qin Li, Yoshihisa Asada, Kazuo Koike. “Clerodane diterpenoids from Tinospora sagittata (Oliv.) Gagnep” Planta Medica, 78, 82–85 (2012). DOI: 10.1055/s-0031-1280163
  25. Xueyan Bi, Wei Li*, Tatsunori Sasaki, Qin Li, Naoko Mitsuhata, Yoshihisa Asada, Qingbo Zhang, Kazuo Koike. “Secoiridoid glucosides and related compounds from Syringa reticulata and their antioxidant activities” Bioorganic & Medicinal Chemistry Letters, 21, 6426-6429 (2011). DOI: 10.1016/j.bmcl.2011.08.089
  26. Pei Chen, Wei Li*, Qin Li, Yinghua Wang, Zhenguo Li, Yefeng Ni, Kazuo Koike. “Identification and quantification of nucleosides and nucleobases in Geosaurus and Leech by Hydrophilic-Interaction Chromatography” Talanta, 85, 1634-1641 (2011). DOI: 10.1016/j.talanta.2011.06.056
  27. Yoshihisa Asada*, Aya Sukemori, Takashi Watanabe, Kuber J. Malla, Takafumi Yoshikawa, Wei Li*, Kazuo Koike, Chin-Ho Chen, Toshiyuki Akiyama, Keduo Qian, Kyoko Nakagawa-Goto, Susan L. Morris-Natschke, Kuo-Hsiung Lee*. “Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.” Organic Letters, 13, 2904–2907 (2011). DOI: 10.1021/ol200889s
  28. Songpei Li, Wei Li*, Yinghua Wang, Yoshihisa Asada, Kazuo Koike. “Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities” Bioorganic & Medicinal Chemistry Letters, 20, 5398-5401 (2010). DOI: 10.1016/j.bmcl.2010.07.110
  29. Hiroyoshi Kato, Wei Li*, Michihiko Koike, Yinghua Wang, Kazuo Koike. “Phenolic glycosides from Agrimonia PilosaPhytochemistry, 71, 1925-1929 (2010). DOI: 10.1016/j.phytochem.2010.08.007
  30. Lijuan Liu, Wei Li*, Tatsunori Sasaki, Yoshihisa Asada, Kazuo Koike. “Juglanone, a novel α-tetralonyl derivative with potent antioxidant activity from Juglans mandshuricaJournal of Natural Medicines, 64, 496-499 (2010). DOI: 10.1007/s11418-010-0435-4