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東邦大学理学部
生物学科
分子発生生物学研究室
村本哲哉
〒274-8510
千葉県船橋市三山2-2-1
Tel: 047-472-5165
研究業績
主要な論文
光操作技術で細胞内シグナル伝達を操作

Optogenetic control of cAMP oscillations reveals frequency-selective transcription factor dynamics in Dictyostelium
Yamashita K, Shimane K, Muramoto T.
Yamashita K, Shimane K, Muramoto T.
Development. 152, dev204403. (2025)
ゲノム編集技術を用いた遺伝子スクリーニング技術を開発

CRISPR/Cas9-based genome-wide screening of Dictyostelium.
Ogasawara T, Watanabe J, Adachi R, Ono Y, Kamimura Y, Muramoto T.
Ogasawara T, Watanabe J, Adachi R, Ono Y, Kamimura Y, Muramoto T.
Scientific Reports. 12, 11215 (2022)
DNA修復と細胞周期の進行を制御するしくみを発見

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones
Brustel J, Muramoto T, Fumimoto K, Ellins J, Pears CJ, Lakin ND.
Brustel J, Muramoto T, Fumimoto K, Ellins J, Pears CJ, Lakin ND.
Nature Communications. 13, 185 (2022)
細胞性粘菌のCRISPRツールボックスの公開

CRISPR Toolbox for Genome Editing in Dictyostelium.
Yamashita K, Iriki H, Kamimura Y, Muramoto T.
Yamashita K, Iriki H, Kamimura Y, Muramoto T.
Frontiers in Cell and Developmental Biology. 9, 721630 (2021)
ゲノム編集可能な標的の制限緩和を実現

Knock-in and precise nucleotide substitution using near-PAMless engineered Cas9 variants in Dictyostelium discoideum.
Asano Y, Yamashita K, Hasegawa A, Ogasawara T, Iriki H, Muramoto T.
Scientific Reports. 11, 11163 (2021)
Asano Y, Yamashita K, Hasegawa A, Ogasawara T, Iriki H, Muramoto T.
Scientific Reports. 11, 11163 (2021)
細胞性粘菌のCRISPR技術の確立

CRISPR/Cas9 mediated targeting of multiple genes in Dictyostelium.
Sekine R, Kawata T, Muramoto T.
Scientific Reports. 8, 8471 (2018).
Sekine R, Kawata T, Muramoto T.
Scientific Reports. 8, 8471 (2018).
転写因子GtaCのシャトリング

Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer.
Cai H. Katoh-Kurasawa M. Muramoto T. Santhanam B. Long Y. Li L. Ueda M. Iglesias P.A. Shaulsky G. and Devreotes P.N.
Science 343, 1249531 (2014).
Cai H. Katoh-Kurasawa M. Muramoto T. Santhanam B. Long Y. Li L. Ueda M. Iglesias P.A. Shaulsky G. and Devreotes P.N.
Science 343, 1249531 (2014).
異なる機能を持つ遺伝子の転写動態

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation.
Muramoto T. Cannon D. Gierlinski M. Corrigan A. Barton G.J. and Chubb J.R.
Proc Natl Acad Sci U S A. 109, 7350-7355. (2012).
Muramoto T. Cannon D. Gierlinski M. Corrigan A. Barton G.J. and Chubb J.R.
Proc Natl Acad Sci U S A. 109, 7350-7355. (2012).
転写頻度のエピジェネティックな継承

Methylation of H3K4 Is required for inheritance of active transcriptional states.
Muramoto T., Müller I., Thomas G., Melvin A., and Chubb J.R.
Current Biology 20, 397-406. (2010).
Muramoto T., Müller I., Thomas G., Melvin A., and Chubb J.R.
Current Biology 20, 397-406. (2010).
シグナル強度に依存した転写ダイナミックス

Digital nature of the immediate-early transcriptional response.
Stevense M. Muramoto T. Müller I. and Chubb J.R.
Development 137, 579-84. (2010).
細胞周期のイメージング解析

Live imaging of the Dictyostelium cell cycle reveals widespread S phase during development, a G2 bias in spore differentiation and a premitotic checkpoint.
Muramoto T. and Chubb J.R.
Development 135, 1647-1657. (2008).