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東邦大学理学部 生物学科 生体調節学研究室

〒274-8510 千葉県船橋市三山2-2-1 習志野学事部入試広報課 TEL 047-472-0666

学術論文

※太字は当研究室の学生,下線部は当研究室の教員です

英文

2023年
1. Ikeda T, Kondo H, Nunomura D, Sato G, Ito M, Yamanaka N, Iwamuro S, Hasunuma I, Kikuyama S, Kobayashi T. Molecular cloning, expression analyses, and physiological roles of cathelicidins in the Bursa of Fabricius of the Japanese quail, Coturnix japonica. Antibiotics 12, 1341, 2023. doi.org/10.3390/antibiotics12081341

2022年
 1. Tanaka Y*,  Yamanaka N*,  Koyano I, Hasunuma I, Kobayashi T,  Kikuyama S,  Iwamuro  S. Dual roles of extracellular histone H3 in host defense: Its differential regionsrResponsible for antimicrobial and cyto-toxic properties and their modes of action. Antibiotics, 11, 1240, 2023. doi: 10.3390/antibiotics11091240. *These authors contributed equally to this study. 
2.  Iwasa A,  Hanaoka N,  Ohwada K,  Iwamuro S,  Toyoda F,  Kikuyama S, Hasunuma I. Cell proliferation and neurogenesis in the adult telencephalon of the newt, Cynops pyrrhogaster. Dev. Growth Differ. 2022 . doi: 10.1111/dgd.12826.

2021年
1. Kikuyama S, Hasunuma I, Okada R. Development of the hypothalamo-hypophyseal system in amphibians with special reference to metamorphosis. Mol. Cell. Endocinol. 524, 2021.

2020年
1. Ogawa D, Suzuki M, Inamura Y, Saito K, Hasunuma I, Kobayashi T, Kikuyama S, Iwamuro S. Antimicrobial property and mode of action of the skin peptides of the Sado wrinkled frog, Glandirana susurra, against animal and plant pathogens. Antibiotics 9, 457, 2020.

2019年
1. Kikuyama S, Okada R, Hasunuma I, Nakada T. Some aspects of the hypothalamic and pituitary development, metamorphosis, and reproductive behavior as studied in amphibians. Gen Comp. Endocrinol. 284, 2019.

2018年

1. Nakano M, Hasunuma I, Minagawa A, Iwamuro S, Yamamoto K, Kikuyama S, Machida T, Kobayashi T. Possible involvement of thyrotropin-releasing hormone receptor 3 in the release of prolactin in the metamorphosing bullfrog larvae. Gen Comp Endocrinol.267, 36–44, 2018.
2. Yamanaka NIwamuro S. Antimicrobial and cell-membrane-penetrating activities of a histone H2B-derived fragment peptide. PEPTIDE SCIENCE 2017, P-141, 2018.

2017年
1. Ogawa D*, Mochitate M*, Furukawa MHasunuma I, Kobayashi T, Kikuyama S, Iwamuro S. Molecular cloning and cunctional characterization of antimicrobial peptides brevinin-1ULf and ulmin-1ULa in the skin of the newly classified Ryukyu brown frog Rana ulma. Zool Sci. 34, 523-531, 2017. *These authors contributed equally to this study. 
2. Nakada T, Toyoda F, Matsuda K, Nakakura T, Hasunuma I, Yamamoto K, Onoue S, Yokosuka M,  Kikuyama S. Imorin: a sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster). Scientific reports 7:41334,2017.

2016年
1. Okada R, Yamamoto K, Hasunuma I, Asahina J, Kikuyama S. Arginine vasotocin is the major adrenocorticotropic hormone-releasing factor in the bullfrog Rana catesbeiana. Gen Comp Endocrinol. 237, 121-130, 2016.

2015年
1. Toyoda F, Hasunuma I, Nakada T, Haraguchi S, Tsutsui K, Kikuyama S. Possible hormonal interaction for eliciting courtship behavior in the male newt, Cynops pyrrhogaster. Gen Comp Endocrinol. 224, 96-103, 2015.

2014年

1. Takeda A, Tsubaki T, Sagae N, Onda Y, Inada Y, Mochizuki T, Okumura K, Kikuyama S, Kobayashi T, Iwamuro S. Bacterial toxin-inducible gene expression of cathelicidin-B1 in the chicken bursal lymphoma-derived cell line DT40: Functional characterization of cathelicidin-B1. Peptides 59, 94-102, 2014..
2. Son YL, Ubuka T, Narihiro M, Fukuda Y, Hasunuma I, Yamamoto K, Beisham DD, Tsutsui K. Molecular basis for the activation of gonadotropin-inhibitory hormone gene transcription by corticosterone. Endocrinology 155, 1817-1826, 2014. 
3.  Nakada T, Hagino-Yamagishi K, Nakanishi K, Yokosuka M, Saito TR, Yoyoda F, Hasunuma I, Nakakura T, Kikuyama S. Expression of G protein in the olfactory receptor neurons of the newt Cynops pyrrhogaster: their unique projection into the olfactory bulbs. J Comp Neurol. 522, 3501-3519, 2014.

 2013年

1.  Konishi YIwamuro SHasunuma I, Kobayashi T, Kikuyama S. Molecular cloning and multifunctional characterization of host defense peptides from the bullfrog Harderian gland with special reference to catesbeianalectin. Zool. Sci. 30,185-190, 2013.
 2.  Hasunuma I, Terakado K. Two novel gonadotropin-releasing hormones (GnRHs) from the urochordate ascidian, Halocynthia roretzi: Implication on the origin of vertebrate GnRH isoforms. Zool. Sci. 30, 311-318, 2013.
 3.  Morita S*, Tagai C*, Shiraishi T, Miyaji K, Iwamuro S. Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus. Peptides 48, 75-82, 2013. *These authors contributed equally to this study. 

2012年
1.  Toyoda F, Hasunuma I, Nakada T, Haraguchi S, Tsutsui K, Kikuyama S. Involvement of the neurosteroid 7α-hydroxypregnenolone in the courtship behavior of the male newt Cynops pyrrhogaster. Horm. Behav.62, 375-380, 2012.
 2.  Haraguchi S, Koyama T, Hasunuma I, Okuyama S, Ubuka T, Kikuyama S, Do Rego JL, Vaudry H, Tsutsui K. Acute stress increases the synthesis of 7α-hydroxypregnenolone, a new key neurosteroid stimulating locomotor activity, through corticosterone action in newts. Endocrinol.153, 794-805, 2012.  

2011年
1.  Koyama T, Conlon JM, Iwamuro S. Molecular cloning and characterization of cDNAs encoding biosynthetic precursors for the antimicrobial peptides japonicin-1Ja, japonicin-2Ja, and temporin-1Ja in the Japanese brown frog, Rana japonica. Zool. Sci.28, 339-347, 2011.
 2.  Takase M, Haraguchi S, Hasunuma I, Kikuyama S, Tsutsui K. Expression of cytochrome P450 side-chain cleavage enzyme mRNA and production of pregnenolone in the brain of the red-bellied newt Cynops pyrrhogaster. Gen. Comp. Endocrinol. 170, 468-474, 2011.
3.  Tagai C*, Morita S*, Shiraishi T, Miyaji K, Iwamuro S. Antimicrobial properties of arginine- and lysine-rich histones and involvement of bacterial outer membrane protease T in their differential mode of actions. PEPTIDES 32, 2003-2009, 2011. *These authors contributed equally to this study.

2010年
1.  Hasunuma I, Iwamuro S, Kobayashi T, Shirama K, Conlon JM, Kikuyama S. Expression of genes encoding antimicrobial peptides in the Harderian gland of the bullfrog Lithobates catesbeianus. Comp. Biochem. Phys. C. Toxicol. Pharmacol. 152, 301-305, 2010.
2. Tazato S, Conlon JM, Iwamuro S. Cloning and expression of genes encoding antimicrobial peptides and bradykinin from the skin and brain of Oki Tago's brown frog, Rana tagoi okiensis. Peptides 31, 1480-1487, 2010.
3.Ohnuma A, Conlon JM, Iwamuro S. Differential expression of genes encoding preprobrevinin-2, prepropalustrin-2, and preproranatuerin-2 in developing larvae and adult tissues of the mountain brown frog Rana ornativentris. Comp. Biochem. Phys. C. Toxicol. Pharmacol. 151, 122-130, 2010.
4.  Conlon, JM, Coquet L, Jouenne T, Leprince J, Vaudry H, Iwamuro S. Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies. Toxicon 55, 430-435, 2010.
5.  Hasunuma I, Toyoda F, Kadono Y, Yamamoto K, Namiki H, Kikuyama S. Localization of three types of arginine vasotocin receptors in the brain and pituitary of the newt Cynops pyrrhogaster. Cell Tissue Res. 342, 437-557, 2010.
6.  Nakano M, Minagawa A, Hasunuma I, Okada R, Tonon MC, Vaudry H, Yamamoto K, Kikuyama S, Machida T, Kobayashi T. D2 Dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary. Gen. Comp. Endocrinol. 168, 287-292, 2010.
7.  Nakano M, Hasunuma I, Okada R, Yamamoto K, Kikuyama S, Machida T, Kobayashi T. Molecular cloning of bullfrog D2 dopamine receptor cDNA: Tissue distribution of three isoforms of D2 dopamine receptor mRNA. Gen. Comp. Endocrinol. 168, 143-148, 2010.
8.  Haraguchi S, Koyama T, Hasunuma I, Vaudry H, Tsutsui K. Prolactin increases the synthesis of 7a-hydroxypregnenolone, a key factor for induction of locomotor activity, in breeding male Newts. Endocrinology 151, 2211-2222, 2010.

2009年
1.  Ohnuma A, Conlon, JM, Iwamuro S. Developmental and thyroid hormone induced expression of preprotemporin genes in the skin of Japanese mountain brown frog Rana ornativentris. Trends in Comparative Endocrinology and Neurobiology: Annals NY Acad. Sci. 1163, 494-496, 2009.
2. Kobayashi T, Takaso A, Tanaka S, Amano M, Takahashi A, Iwamuro S, Machida T. Demonstration of the proopiomelaocortin signalling system in the primary immune organ, the bursa of Fabricius, of the quail. Trends in Comparative Endocrinology and Neurobiology: Annals NY Acad. Sci. 1163, 441-443, 2009.
3. Kawaguchi M, Fujita H, Yoshizaki N, Hiroi J, Okouchi H, Nagakura Y, Noda T, Watanabe S, Katayama S, Iwamuro S, Nishida M, Iuchi I, Yasumasu S. Different hatching strategies in embryos of two species, Pacific herring Clupea pallasii and Japanese anchovy Engraulis japonicus, that belong to the same order clupeiformes, and their environmental adaptation. J. Exp. Zool. (Mol. Dev. Evol.) 312B, 95-107, 2009.

2008年
1. Kawasaki H, Iwamuro SGoto Y, Nielsen Per F, Conlon JM. Characterization of a hemolytic protein, identified as histone H4, from the skin of the Japanese tree frog Hyla japonica (Hylidae). Comp. Biochem. Phys. B 149, 120-125, 2008.
2. Shimada Y, Fukuda T, Aoki T, Yukawa T, Iwamuro S, Ohkawa K, Takada K. A protocol for immunoaffinity separation of the accumulated ubiquitin-protein conjugates solubilized with sodium dodecyl sulfate. Anal. Biochem. 377,77-82, 2008.
3. Koyama TIwamuro S. Molecular cloning of a cDNA encoding atypical antimicrobial and cytotoxic brevinin-1Ja from the skin of the Japanese brown frog, Rana japonica. Zool. Sci. 25, 487-491, 2008.
4. Kawasaki H, Koyama T, Conlon JM, Yamakura F, Iwamuro S. Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Biochimie 90, 1693-1702, 2008.
5. Chowdhury VS, Yamamoto K, Saeki I, Hasunuma I, Shimura T, Tsutsui K. Melatonin stimulates the release of growth hormone and prolactin by a possible induction of the expression of frog growth hormone-releasing peptide and its related peptide-2 in the amphibian hypothalamus. Endocrinology 149, 962-970, 2008.
6.Bentley GE, Ubuka T, McGuire NL, Chowdhury VS, Morita Y, Yano T, Hasunuma I, Binns M, Wingfield JC, Tsutsui K. Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system. Gen. Comp. Endocrinol.156, 34-43, 2008.

2007年
1. Ohnuma A, Conlon JM, Yamaguchi KKawasaki H, Coquet L, Leprince J, Jouenne T, Vaudry H, Iwamuro S. Antimicrobial peptides from the skin of the Japanese mountain brown frog Rana ornativentris: evidence for polymorphism among preprotemporin mRNAs. Peptides 28, 524-532, 2007.
2. Suzuki HIwamuro SOhnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor C, Abel PW, Conlon J M. Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog, Rana sakuraii. Peptides 28, 505-514, 2007.
3. Hayashi H, Nishimoto A, Oshima N, Iwamuro S. Expression of the estrogen receptor α gene in the anal fin of Japanese medaka, Oryzias latipes, by environmental concentrations of bisphenol A. J. Toxicol. Sci. 32, 91-96, 2007.
4. Conlon JM, Kokodziejek J, Nowotny N, Leprince J, Vaudry H, Coquet L, Jouenne T, Iwamuro S.Cytolytic peptides belonging to the brevinin-1 and brevinin-2 families isolated from the skin of the Japanese brown frog, Rana dybowskii. Toxicon 50, 746-756, 2007.
5. Suzuki H, Conlon JM, Iwamuro S. Evidence that the genes encoding the melittin-related peptides in the skins of the Japanese frogs Rana sakuraii and Rana tagoi are not orthologous to bee venom melittin genes: developmental- and tissue-dependent gene expression. Peptides 28, 2061-2068, 2007.
6. Azuma H, Kobayashi M, Nakamura M, Suzuki N, Yashima S, Iwamuro S, Ikegame M, Yamamoto T, Hattori A. Two osteoclastic markers expressed in multinucleate osteoclasts of goldfish scales. Biochem. Biophys. Res. Commun. 362, 594-600, 2007.
7. Hasunuma I, Sakai T, Nakada T, Toyoda F, Namiki H, Kikuyama S. Molecular cloning of three types of arginine vasotocin receptor in the newt, Cynops pyrrhogaster. Gen. Comp. Endocrinol. 151, 252-258, 2007.

2006年
1. Ohnuma A, Conlon JM, Kawasaki HIwamuro S. Developmental and triiodothyronin-induced expression of genes encoding preprotemporin in the skin of Tago's brown frog Rana tagoi. Gen. Comp. Endocrinol. 146, 242-250, 2006.
2. Conlon JM, Al-Ghaferi N, Abraham B, Sonnevend A, Coquet L, Leprince J, Jouenne T, Vaudry H,Iwamuro S. Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. Comp. Biochem. Phys.C 143, 42-49, 2006.
3. Iwamuro S, Nakamura M, Ohnuma A, Conlon JM. Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.Peptides 27, 2124-2128, 2006.
4. Iwamuro S, Yamada M, Kato M, Kikuyama S. Effects of bisphenol A on thyroid hormone-dependent up-regulation of thyroid hormone receptor α and β and down-regulation of retinoid X receptor γ in Xenopus tail culture. Life Sciences 79, 2165-2171, 2006.

2005年
1. Conlon JM, Sonnevend A, Jouenne T, Coquet L, Cosquer D, Vaudry H, Iwamuro S. A family of acyclic brevinin-1 peptides from the skin of the Ryukyu brown frog Rana okinavana. Peptides 26, 185-190, 2005.
2. Yoshikubo H, Susuki N, Takemura K, Hoso M, Yashima SIwamuro S, Takagi Y, Tabata MJ, Hattori A. Osteoblastic activity and estrogenic response in the regenerating scale of goldfish, a good model of osteogenesis. Life Sci.73, 2699-2709, 2005.
3.  Hasunuma I, Toyoda F, Yamamoto K, Yamashita M, Kikuyama S. Localization of prolactin receptor in the newt brain. Cell Tissue Res. 320, 477-485, 2005.
4. Toyoda F, Hasunuma I, Yamamoto K, Yamashita M, Kikuyama S. Prolactin acts centrally to enhance newt courtship behavior. Gen. Comp. Endocrinol. 141, 172-177, 2005.

2004年
1. Conlon JM, Sonnevend A, Patel M, Al-Dhaher K, Nielsen PF, Kolodzjejek J, Nowotny N, Iwamuro S, Pal T. A familiy of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica. Regul. Peptides 118, 135-141, 2004.
2. Iwamuro SAikawa N, Yamada M, Kikuyama S. In vitro effect of bisphenol A on the thyroid hormone receptor gene expression in the Xenopus tail and testis. Trends in Comp. Endocrinol, 590-592, 2004.
3.  Hasunuma I, Yamamoto K, Kikuyama S. Molecular cloning of bullfrog prolactin receptor cDNA: changes in prolactin receptor mRNA level during metamorphosis. Gen. Comp. Endocrinol. 138, 200-201, 2004.
4. Matsukawa H, Hasunuma I, Kato T, Yamamoto K, Miura S, Fujita T, Kikuyama S. Expression of prolactin receptor mRNA in the abdominal gland of the newt Cynops ensicauda. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 138, 79-88, 2004.

2003年
1. Kawasaki H, Isaacson T, Iwamuro S, Conlon, JM. A protein with antimicrobial activity in the skin of Schlegel's green tree frog Rhacophorus schlegelii (Rhacophoridae) identified as histone H2B. Biochem. Biophys. Res. Commun. 312, 1082-1086, 2003.
2.Iwamuro S, Sakakibara M, Terao M, Ozawa A, Kurobe C, Shigeura T, Kato M, Kikuyama S. Teratogenic and anti-metamorphic effects of bisphenol A on embryonic and larval Xenopus laevis. Gen. Comp. Endocrinol. 133, 189-198, 2003.
3.Conlon JM, Sonnevend A, Patel M, Camasandudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pal T. A melittin-related peptide from the skin in the Japanese frog, Rana tagoi, with antimicorbial and cytolytic properties. Biochem. Biophys. Res. Commun. 306, 496-500, 2003.

2002年
1. Isaacson T, Soto AM, Iwamuro S, Knoop FC, Conlon JM. Antimicrobial peptides with a typical structural features from the skin of the Japanese brown frog Rana japonica. Peptides 23, 419-425, 2002.

2001年
1. Kim, J. B., Iwamuro, S., Knoop, F.C., and Conlon, J. M. Antimicrobial peptides from the skin of the Japanese mountain brown frog, Rana ornativentris. J. Peptide Research 58, 349-356, 2001.
2. Takahashi N, Hasunuma I, Iwata T, Umezawa K, Yamamoto K, Marin A, Perroteau I, Vellano C, Kikuyama S. Molecular cloning of newt prolactin (PRL) cDNA: effect of temperature on PRL mRNA expression. Gen. Comp. Endocrinol. 121, 188-195, 2001.

2000年以前
1. Aida T, Iwamuro S, Miura S, Kikuyama S. Changes of pituitary proopiomelanocortin mRNA levels during metamorphosis of the bullfrog larvae. Zool Sci. 16, 255-260, 1999.
2. Iwamuro S, Saeki M, Kato S. Multi-ubiquitination of a nascent membrane protein produced in a rabbit reticulocyte lysate. J. Biochem. 126, 48-53, 1999.
3. Kim NS, Yamaguchi T, Sekine S, Saeki M, Iwamuro S, Kato S. Cloning of human polyubiquitin cDNAs and ubiquitin-binding assay using its in vitro translation product. J. Biochem. 124, 35-39, 1998.
4. Oshima N, Makino M, Iwamuro S, Bern H. A. Pigment dispersion by prolactin in cultured xanthophores and erythrophores of some fish species. J. Exp. Zool. 275, 45-52, 1996.
5. Ulisse S, Iwamuro S, Tata JR. Differential responses to ligands of overexpressed thyroid hormone and retinoid X receptors in a Xenopus cell line and in vivo. Mol. Cell. Endocrinol. 126, 17-24, 1997.
6. Aida T, Oguchi A, Iwamuro S, Yamamoto K, Kikuyama S. Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells. Zool. Sci. 14, 827-831, 1997.
7. Aida T, Oguchi A, Iwamuro S, Yamamoto K, Kikuyama S. Stimulation by proopiomelanocortin-derived peptides of GH and PRL release by bullfrog dispersed anterior pituitary cells. Adv. Comp. Endocrinol. 2, 1033-1037, 1997.
8. Iwamuro S, Tata JR. Contrasting patterns of expression of thyroid hormone and retinoid X receptor genes during hormonal manipulation of Xenopus tadpole tail regression in culture. Mol. Cell. Endocrinol. 113, 235-243, 1995.
9. Iwamuro S, Hayashi H, Kikuyama S. An additional arginine-vasotocin-related peptide, vasotocinyl-Gly-Lys, in Xenopus neurohypophysis. Biochim. Biophys. Acta 1176, 143-147, 1993.
10. Iwamuro S, Tanaka S, Sugihara S, Nomizu M, Hayashi H, Kikuyama S. Secretion of immunoreactive joining peptide by the pituitary of the bullfrog, Rana catesbeiana. Annals NY Acad. Sci. 680, 552-554, 1993.
11. Iwamuro S, Hayashi H, Delbende C, Vaudry H, Kikuyama S. Purification and characterization of joining peptide and N-terminal peptide of proopiomelanocortin from the pars distalis of the bullfrog pituitary. Peptides 13, 729-735, 1992.
12.  Iwamuro S, Hayashi H, Yamashita M, Kikuyama S. Arginine vasotocin (AVT) and AVT-related peptide are major aldosterone-releasing factors in the bullfrog neurointermediate lobe. Gen. Comp. Endocrinol. 84. 412-418, 1991.
13. Iwamuro S, Kuwagaki D, Kikuyama S. Effect of arginine vasotocin (AVT) and AVT-related peptide on skin gland secretion in Xenopus laevis. Zool. Sci. 8, 743-746, 1991.
14. Niinuma K, Mamiya N, Yamamoto K, Iwamuro S, Vaudry H, Kikuyama S. Plasma concentration of aldosterone and prolactin in metamorphosing toad tadpoles. Bull. Sci. Engin. Res. Lab., Waseda Univ. 12, 17-21, 1989.
15.  Iwamuro S, Mamiya N, Kikuyama S. Pituitary-hormone dependent aldosterone secretion in Xenopus laevis. Zool. Sci. 6, 345-350, 1989.
16. Kikuyama S, Suzuki, MR.,  Iwamuro, S. Elevation of plasma aldosterone levels of tadpoles at metamorphic climax. Gen. Comp. Endocrinol. 63, 186-190, 1986.
17. Iwamuro S, Yamaguchi Y, Kobayashi, T, Kikuyama S. Effect of neurohypophyseal hormones on thyroxin-induced resorption of tadpole tail in vitro. Proc. Japan Acad. vol. 61, Ser. B, No. 9, 441-443, 1985.

和文

  1. 桜井英博、椎名乾平、中野美智子、並木秀男、岩室祥一、澤村京一 「大学入試から見た高校間格差の研究(第1報)−神奈川県下高校に関する分析−」、早稲田教育評論第8巻第1号、43-58ページ、1994年.