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東邦大学理学部
生物分子科学科
永田研究室

〒274-8510
千葉県船橋市三山2-2-1

発表論文

 
  1. Shibata, T., Makino, A., Ogata, R., Nakamura, S., Ito, T., Nagata, K., Terauchi, Y., Oishi, T., Fujieda, M., Takahashi, Y., Ato, M.: Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization.  J. Clin Invest. 130:3021, 2020 
  2. Yamaguchi, Y., Kaida, K., Suenaga, Y., Akihito, I., Kobayashi, Y., Nagata, K.: Aged-related dysfunction of p53-regulated phagocytic activity in macrophages.  Biochem. Biophys. Res. Commun. 529: 462, 2020 
  3. Takizawa, S., Funakoshi, T., Yatsu, T., Nagata, K., Aigaki, T., Machida, S., and Ishigami. A.: Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance.  Sci. Rep. 9: 4702, 2019.
  4. Kawashima, S., Funakoshi, T., Sato, Y., Saito, N., Ohsawa, H., Kurita K., Nagata, K., Yoshida, M., and Ishigami. A.: Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage.  Sci. Rep. 8: 16199, 2018. 
  5. Otaki, M., Hirano, T., Yamaguchi, Y., Kaida, K., Koshika, S., Nagata, K., Nishimura, M., Kakinuma, S., Shimada, Y., and Kobayashi, K.: Changes in the function and phenotype of resident peritoneal macrophagesafter housing in an enriched environment.  Int. Immunopharmac. 65: 44-49, 2018. 
  6. Chen, Y., Takikawa, M., Tsutsumi, S., Yamaguchi, Y., Okabe, A., Shimada, M., Kawase, T., Sada, A., Ezawa, I., Takano, Y., Nagata, K. Suzuki, Y., Semba, K., Aburatani, H., and Ohki, R.: PHLDA1, another PHLDA family protein that inhibits Akt.   Cancer Sci. 109: 3532-3542, 2018 
  7. Takahashi, R., Ishigami, A., Kobayashi Y., and Nagata, K.: Skewing of peritoneal resident macrophages toward M1-like is involved in enhancement of inflammatory responses induced by secondary necrotic neutrophils in aged mice. Cellular Immunol. 304-305: 44-48, 2016.
  8. Sekiguchi, S., Tomisawa, Y., Ohki, T., Tsuboi, K., Nagata, K., and Kobayashi, Y.: Suppression of macrophage-mediated phagocytosis of apoptotic cells by soluble β-glucan due to a failure of PKC-βII translaction.  Int. Immunopharm. 31: 195-199, 2016.
  9. Takahashi, R., Totsuka, S., Ishigami, A., Kobayashi Y., and Nagata, K.: Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice. Geriatr. Gerontol. Int. 16: 135-142, 2016.
  10. Suzuki, J., Hamada, E., Shodai, T., Kamoshida, G., Kudo, S., Itoh, S., Koike, J., Nagata, K., Irimura, T., and Tsuji, T.: Cytokine Secretion from human monocytes potentiated by P-selectin-mediated cell adhesion. International archives of Allergy and immunology. 160: 152-160, 2013.
  11. Iwasa, T., Takahashi, R., Nagata, K., and Kobayashi, Y.: Suppression of MIP-2 production by annexin A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils. Biochemica et Biophysica Acta. 1822: 204-211, 2012.
  12. Yi, S., Kakinuma, S., Nishimura, M., Kobayashi, Y., Nagata, K., and Shimada, Y.: Interleukin-9 Receptor Gene is Transcriptionally Regulated by Nucleolin in T-Cell Lymphoma Cells. Molecular Carcinogenesis. 51: 619-627, 2012.
  13. Sasaki, S., Tamaki, Y., Nagata, K., and Kobayashi, Y.: Regulation of the estrous cycle by neutrophils via opioid peptides. J. Immunol. 187: 774-780, 2011.
  14. Nakayama, E., Shiratsuchi, Y., Kobayashi, Y., and Nagata, K.: The importance of infiltrating neutrophils in SDF-1 production leading to regeneration of the thymus after whole-body X-irradiation. Cellular Immunol. 268: 24-28, 2011.
  15. Shibata, T., Nagata, K., and Kobayashi, Y.: Apoptotic neutrophils and nitric oxide regulate cytokine production by IFN-γ-stimulated macrophages. Cytokine 53: 191-195, 2011.
  16. Shibata, T., Nagata, K., and Kobayashi, Y.: The mechanism underlying the appearance of late apoptotic neutrophils and subsequent TNF-α production at a late stage during Staphylococcus aureus bioparticle-induced peritoneal inflammation in inducible NO synthase-deficient mice. Biochemica et Biophysica Acta. 1802: 1105-1111, 2010.
  17. Sasaki, S., Nagata, K., and Kobayashi, Y.: Regulation of the estrous cycle by neutrophil infiltration into the vagina. Biochem. Biophys. Res. Commun. 382: 35-40, 2009.
  18. Terasawa, M., Nagata, K., and Kobayashi, Y.: Neutrophils and monocytes transport tumor cell antigens from the peritoneal cavity to secondary lymphoid tissues.  Biochem. Biophys. Res. Commun. 377: 589-594, 2008.
  19. Yamazaki, T., Nagata, K., and Kobayashi, Y.: Cytokine production by M-CSF- and GM-CSF-induced mouse bone marrow-derived macrophages upon coculturing with late apoptotic cells. Cellular Immunol. 251: 124-130, 2008.
  20. Hatano, M., Sasaki, S., Ohata, S., Shiratsuchi, Y., Yamazaki, Y., Nagata, K., and Kobayashi, Y.: Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis.  Cellular Immunol. 251: 25-30, 2008.
  21. Fujiwara, H., Yamazaki, T., Uzawa, A., Nagata, K., and Kobayashi, Y.: Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice. Biochem. Biophys. Res. Commun. 369: 432-436, 2008.
  22. Shibata, T., Nagata, K., and Kobayashi, Y.: Cutting Edge; A critical role of nitrogen oxide in preventing inflammation upon apoptotic cell clearance. J. Immunol. 179: 3402-3406, 2007.
  23. Tanimoto, N., Terasawa, M., Nakamura, M., Kegai, D., Aoshima, N., Kobayashi Y., and Nagata, K.: Involvement of KC, MIP-2, and MCP-1 in leukocyte infiltration following injection of necrotic cells into the peritoneal cavity.  Biochem. Biophys. Res. Commun. 361: 533-536, 2007.
  24. Itoh, S., Susuki, C., Takeshita, C., Nagata, K., and Tsuji, T.: Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomains. J. Leukoc. Biol. 81: 1414-1421, 2007.
  25. Saijo, S., Nagata, K., Masuda, J., Matsumoto, I., and Kobayashi, Y.: Discrimination of early and late apoptotic cells by MDB-phosphatidylserine-labelling and time-lapse observation of phagocytosis of apoptotic cells by macrophages. J. Biochem. 141: 301-307, 2007.
  26. Shiratsuchi, Y., Iyoda, T., Tanimoto, N., Kegai D., Nagata, K., and Kobayashi, Y.: Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production. J. Leukoc. Biol. 81: 412-420, 2007.
  27. Shibata, T., Nagata, K., and Kobayashi, Y.: Pivotal Advance; A suppressive role of nitric oxide in MIP-2 production by macrophages upon coculturing with apoptotic cells.  J. Leukoc. Biol. 80: 744–752, 2006.
  28. Saijo, S., Nagata, K., Nakano, Y., Tobe, T. and Kobayashi, Y.: Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells. Biochem. Biophys. Res. Commun. 334: 1180-1183, 2005.
  29. Iyoda, T., Nagata, K., Akashi, M. and Kobayashi, Y.: Neutrophils accelerate macrophage-mediated digestion of apoptotic cells in vivo as well as in vitro.  J. Immunol. 175: 3475-3483, 2005.
  30. Tsuchiya, K., Kawano, Y., Kojima, T., Nagata, K., Takao, T., Okada, M., Shinohara, H., Maki, K., Toyama-Sorimachi, N., Miyasaka, N., Watanabe, M., and Karasuyama, H.: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS lett. 537: 203-209, 2003.
  31. Kouro, T., Nagata, K., Takaki, S., Karasuyama, H. and Takatsu, K.: Bruton's tyrosine kinase (Btk) is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int. Immunol. 13: 485-493, 2001.
  32. Kinoshita,T., Nagata, K., Sorimachi, N., Kayasuyama, H., Sekigucgi, T., Miyajima, A.: Oncostatin M Suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microeviroment. Exp. Hemtol. 29: 1091-1097, 2001.
  33. Karasuyama, K., Tuganezawa, K., Kiyokawa, N., Matsuo, Y., Kitamura, F., Toyama-Sorimachi, N., Nagata, K., Kuida, K., and Fujimoto, J.: Expression profile of pre-B cell receptor components in acute lymphoblastic leukemia and its application to the diagnosis and classification of the disease. Tissue Antigens 55 (Supplement no.1): 20-21, 2000.
  34. Koike, J., Nagata, K., Kubo S., Tsuji, T., and Irimura T.: Density-dependent induction of TNF-α release from human monocytes by immobilized P-selectin. FEBS lett. 477: 84-88, 2000.
  35. Nagata, K., Tsuji, T., Matsushima, K., Hanai, N. and Irimura, T.: Redistribution of selectin counter-ligands induced by cytokines. Int. Immunol. 12(4): 487-492, 2000.
  36. Maki, K., Nagata, K., Kitamura, F., Takemori, T. and Karasuyama, H.: Igβ signaling regulates locus accessibility for ordered Ig gene rearrangements.  J. Exp. Med. 191: 1333-1340, 2000.
  37. Endo, J., Toyama-Sorimachi, N., Taya, C., Kuramochi-Miyagawa, S., Nagata, K., Kuida, K., Takashi, T., Yonekawa, H., Yoshizawa, Y., Miyasaka, N. and Karasuyama, H.: Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS lett. 468: 234-238, 2000.
  38. Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K. S. and Karasuyama, H.: The Igα/Igβ heterodimer on μ-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity 7: 559-570, 1997.
  39. Karasuyama, H., Nakamura, T., Nagata, K., Kuramochi, S., Kitamura, F. and Kuida, K.: The roles of preB cell receptor in early B cell development and its signal transduction. Immunol. Cell Biol., 75: 209-216, 1997.
  40. Tsuji, T., Nagata, K., Koike, J., Todoroki, N., and Irimura, T.: Induction of superoxide anion production from monocytes and neutrophils by activated platelets through the P-selectin-sialyl Lewis X interaction. J. Leukoc. Biol. 56: 583-587, 1994.
  41. Nagata, K., Tsuji, T., Hanai, N., and Irimura,T.: Role of O-linked carbohydrate chains on leukocyte cell membranes in platelet-induced leukocyte activation.   J. Biol. Chem. 269: 23290-23295, 1994.
  42. Nagata, K., Tsuji, T., Todoroki,N., Katagiri, Y., Tanoue, K., Yamazaki, H., Hanai, N., and Irimura, T.: Activated platelets induced superoxide anion release by monocytes and neutrophils through P-selectin (CD62). J. Immunol. 151: 3267-3273, 1993.