English TOP
Address
Sone Laboratory
Department of Biomolecular Science,
Faculty of Science,
Toho University
Miyama2-2-1, Funabashi,
Chiba, 274-8510 Japan
Current Research
We study neurobiology by genetic methods using the fruit fly, Drosophila melanogaster. Our research aims to elucidate the molecular mechanisms that underlie brain functions that control complicated animal behavior and brain dysfunctions such as neurodegenerative diseases.
Regulatory mechanisms of intracellular protein trafficking and their relevance to brain function and dysfunction.
Major parts of synaptic proteins are synthesized in neuronal cell bodies and are then transported to synaptic terminals through axons. We are interested in the role of the regulatory mechanisms of intracellular protein trafficking in the formation of neural circuits and in neurodegeneration.
Our research primarily focuses on two proteins, Hikaru genki (HIG) and Amyloid precursor protein (APP). Although both of these two proteins are synaptic proteins, they are transported to synapses only at specific developmental stages. In insects, neuronal networks of the adult brain are formed at the pupal stage. HIG and APP proteins are transported to synapses at the early pupal stages when the formation of synapses is actively occurring. However, the transportation of HIG and APP is suppressed at later stages. Our goal is to elucidate the mechanisms that control the differential trafficking of these proteins. Additionally, we hope to reveal the significance of this regulation in neural development and neurodegeneration.
APP is a well-known causative protein of Alzheimer's disease, which is a major cause of dementia. We recently succeeded in identifying a novel gene that is required for the synaptic transport of APP. We named this gene yata after a legendary crow that guided an ancient Japanese emperor to his destination. In null mutants of the yata gene, the synaptic transport of APP is impaired and APP accumulates in the endoplasmic reticulum. Intriguingly, null mutants of the yata gene display phenotypes that include signs of neurodegeneration, such as tissue vacuolization, shortened lifespan and brain volume reduction. Knockout mice for the yata ortholog have been reported to display the degeneration of motor neurons, which suggests that yata has an evolutionarily conserved role in the prevention of neurodegeneration. Our aim is to elucidate the mechanisms that cause neurodegeneration in yata mutants and to determine their relevance in Alzheimer's disease.
References:
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
Masaki Sone, Atsuko Uchida, Ayumi Komatsu, Emiko Suzuki, Ikue Ibuki, Megumi Asada, Hiroki Shiwaku, Takuya Tamura, Mikio Hoshino, Hitoshi Okazawa, Yo-ichi Nabeshima
PLoS One, 4, e4466 (2009).
Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.
Koto Furotani, Keisuke Kamimura, Takaaki Yajima, Minoru Nakayama, Rena Enomoto, Takuya Tamura, Hitoshi Okazawa, Masaki Sone
PLoS One, 13, e0204048 (2018).
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
Masaki Sone, Atsuko Uchida, Ayumi Komatsu, Emiko Suzuki, Ikue Ibuki, Megumi Asada, Hiroki Shiwaku, Takuya Tamura, Mikio Hoshino, Hitoshi Okazawa, Yo-ichi Nabeshima
PLoS One, 4, e4466 (2009).
Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.
Koto Furotani, Keisuke Kamimura, Takaaki Yajima, Minoru Nakayama, Rena Enomoto, Takuya Tamura, Hitoshi Okazawa, Masaki Sone
PLoS One, 13, e0204048 (2018).
Drosophila models of neurodegenerative diseases.
We study Drosophila models of polyglutamine diseases such as Huntington's disease, Spinocerebellar ataxia type 1 (SCA1) and Frontotemporal lober degeneration (FTLD).
Reference:
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku, Masaki Sone, Chisato Yoshida, Masahisa Katsuno, Yoshinobu Eishi, Miho Murata, J. Paul Taylor, Erich E. Wanker, Kazuteru Kono, Satoshi Tashiro, Gen Sobue, Albert R. La Spada, Hitoshi Okazawa
Nature Commun., 4, 1816 (2013).
Loss of function of VCP/TER94 causes neurodegeneration.
Kohei Tsumaki, Christian JF Bertens, Minoru Nakayama, Saya Kato, Yuki Jonao, Ayu Kuribayashi, Konosuke Sato, Shota Ishiyama, Momoko Asakawa, Riko Aihara, Yuki Yoshioka, Hidenori Homma, Hikari Tanaka, Kyota Fujita, Hitoshi Okazawa, Masaki Sone
Disease Models Mech., 17, dmm050359 (2024).
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku, Masaki Sone, Chisato Yoshida, Masahisa Katsuno, Yoshinobu Eishi, Miho Murata, J. Paul Taylor, Erich E. Wanker, Kazuteru Kono, Satoshi Tashiro, Gen Sobue, Albert R. La Spada, Hitoshi Okazawa
Nature Commun., 4, 1816 (2013).
Loss of function of VCP/TER94 causes neurodegeneration.
Kohei Tsumaki, Christian JF Bertens, Minoru Nakayama, Saya Kato, Yuki Jonao, Ayu Kuribayashi, Konosuke Sato, Shota Ishiyama, Momoko Asakawa, Riko Aihara, Yuki Yoshioka, Hidenori Homma, Hikari Tanaka, Kyota Fujita, Hitoshi Okazawa, Masaki Sone
Disease Models Mech., 17, dmm050359 (2024).
Molecular mechanisms that control animal behavior.
We study the Drosophila mutants, still life (sif) and hikaru genki (hig), both of which display sluggishness. sif encodes an activator of the small G-protein, Rac, and is specifically localized in synaptic periactive zones, which are specialized submembranous regions that regulate synaptic development. hig encodes a protein that has an immunoglobulin domain and complement-binding domains and that is secreted to synaptic clefts. We hope to elucidate the mechanisms that underlie the abnormal behavior of these mutants.
References:
Synaptic development is controlled in the periactive zones of Drosophila synapses.
Masaki Sone, Emiko Suzuki, Mikio Hoshino, Dongmei Hou, Hiroshi Kuromi, Masaki Fukata, Shinya Kuroda, Kozo Kaibuchi, Yo-ichi Nabeshima, Chihiro Hama
Development, 127, 4157-4168 (2000).
Synaptic development is controlled in the periactive zones of Drosophila synapses.
Masaki Sone, Emiko Suzuki, Mikio Hoshino, Dongmei Hou, Hiroshi Kuromi, Masaki Fukata, Shinya Kuroda, Kozo Kaibuchi, Yo-ichi Nabeshima, Chihiro Hama
Development, 127, 4157-4168 (2000).
Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers.
Masaki Sone, Mikio Hoshino, Emiko Suzuki, Shinya Kuroda, Kozo Kaibuchi, Hideki Nakagoshi, Kaoru Saigo, Yo-ichi Nabeshima, Chihiro Hama
Science, 275, 543-547 (1997).
Masaki Sone, Mikio Hoshino, Emiko Suzuki, Shinya Kuroda, Kozo Kaibuchi, Hideki Nakagoshi, Kaoru Saigo, Yo-ichi Nabeshima, Chihiro Hama
Science, 275, 543-547 (1997).
Publications
Loss of function of VCP/TER94 causes neurodegeneration.
Kohei Tsumaki, Christian JF Bertens, Minoru Nakayama, Saya Kato, Yuki Jonao, Ayu Kuribayashi, Konosuke Sato, Shota Ishiyama, Momoko Asakawa, Riko Aihara, Yuki Yoshioka, Hidenori Homma, Hikari Tanaka, Kyota Fujita, Hitoshi Okazawa, Masaki Sone
Disease Models Mech., 17, dmm050359 (2024).
Kohei Tsumaki, Christian JF Bertens, Minoru Nakayama, Saya Kato, Yuki Jonao, Ayu Kuribayashi, Konosuke Sato, Shota Ishiyama, Momoko Asakawa, Riko Aihara, Yuki Yoshioka, Hidenori Homma, Hikari Tanaka, Kyota Fujita, Hitoshi Okazawa, Masaki Sone
Disease Models Mech., 17, dmm050359 (2024).
Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression.
Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejon, Irene Basili, Flavia Bernardi, Patricia Benites Goncalves da Silva, Wanchen Wang, Owen Chapman, Liying Yang, Maki Jami, Kayo Nishitani, Yukimi Arai, Zhize Xiao, Hua Yu, Valentina Lo Re, Véronique Marsaud, Julie Talbot, Bérangère Lombard, Damarys Loew, Maho Jingu, Konstantin Okonechnikov, Masaki Sone, Norio Motohashi, Yoshitsugu Aoki, Stefan M Pfister, Lukas Chavez, Mikio Hoshino, Reo Maruyama, Olivier Ayrault, Daisuke Kawauchi
Dev. Cell, S1534-5807, 00330-7 (2024).
Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejon, Irene Basili, Flavia Bernardi, Patricia Benites Goncalves da Silva, Wanchen Wang, Owen Chapman, Liying Yang, Maki Jami, Kayo Nishitani, Yukimi Arai, Zhize Xiao, Hua Yu, Valentina Lo Re, Véronique Marsaud, Julie Talbot, Bérangère Lombard, Damarys Loew, Maho Jingu, Konstantin Okonechnikov, Masaki Sone, Norio Motohashi, Yoshitsugu Aoki, Stefan M Pfister, Lukas Chavez, Mikio Hoshino, Reo Maruyama, Olivier Ayrault, Daisuke Kawauchi
Dev. Cell, S1534-5807, 00330-7 (2024).
Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation.
Ken-ichi Dewa, Nariko Arimura, Wataru Kakegawa, Masayuki Itoh, Toma Adachi, Satoshi Miyashita, Yukiko U Inoue, Kento Hizawa, Kei Hori, Natsumi Honjoya, Haruya Yagishita, Shinichiro Taya, Taisuke Miyazaki, Chika Usui, Shoji Tatsumoto, Akiko Tsuzuki, Hirotomo Uetake,Kazuhisa Sakai, Kazuhiro Yamakawa, Takuya Sasaki, Jun Nagai,Yoshiya Kawaguchi, Masaki Sone, Takayoshi Inoue, Yasuhiro Go, Noritaka Ichinohe, Kozo Kaibuchi, Masahiko Watanabe, Schuichi Koizumi, Michisuke Yuzaki, Mikio Hoshino
Nature Commun., 15, 458 (2024).
Ken-ichi Dewa, Nariko Arimura, Wataru Kakegawa, Masayuki Itoh, Toma Adachi, Satoshi Miyashita, Yukiko U Inoue, Kento Hizawa, Kei Hori, Natsumi Honjoya, Haruya Yagishita, Shinichiro Taya, Taisuke Miyazaki, Chika Usui, Shoji Tatsumoto, Akiko Tsuzuki, Hirotomo Uetake,Kazuhisa Sakai, Kazuhiro Yamakawa, Takuya Sasaki, Jun Nagai,Yoshiya Kawaguchi, Masaki Sone, Takayoshi Inoue, Yasuhiro Go, Noritaka Ichinohe, Kozo Kaibuchi, Masahiko Watanabe, Schuichi Koizumi, Michisuke Yuzaki, Mikio Hoshino
Nature Commun., 15, 458 (2024).
Control of synaptic levels of nicotinic acetylcholine receptor by the sequestering subunit Dalpha5 and secreted scaffold protein Hig.
Minoru Nakayama, Osamu Nishimura, Yuhi Nishimumra, Miwa Kitaichi, Shigehiro Kuraku, Masaki Sone, Chihiro Hama
J. Neurosci., 43, 3989-4004 (2023).
Minoru Nakayama, Osamu Nishimura, Yuhi Nishimumra, Miwa Kitaichi, Shigehiro Kuraku, Masaki Sone, Chihiro Hama
J. Neurosci., 43, 3989-4004 (2023).
Design and synthesis of gene-directed caged cyclin nucleotide exhibiting cell type specificity.
Akinobu Z Suzuki, Taichi Sakano, Hirona Sasakim Rei Watahiki, Masaki Sone, Kazuki Horikawa, Toshiaki Furuta
Chem. Commun, 57, 5630-5633 (2021).
Akinobu Z Suzuki, Taichi Sakano, Hirona Sasakim Rei Watahiki, Masaki Sone, Kazuki Horikawa, Toshiaki Furuta
Chem. Commun, 57, 5630-5633 (2021).
DNA damage in embryonic neural stem cell determines FTLD's fate via early stage neuronal necrosis.
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xialcen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Life Sci. Alliance, 4, e202101022 (2021).
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xialcen Jin, Yong Huang, Yuki Yoshioka, Christian JF Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa
Life Sci. Alliance, 4, e202101022 (2021).
Cyclin D1 coontrols development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1.
Satoshi Miyashita, Tomoo Owa, Yusuke Seto, Mariko Yamashita, Shogo Aida, Masaki Sone, Kentaro Ichijo, Tomoki Nishioka, Kozo Kaibuchi, Yoshiiya Kawaguchi, Shinichiro Taya, Mikio Hoshino
EMBO J., 40, e105712 (2021).
Satoshi Miyashita, Tomoo Owa, Yusuke Seto, Mariko Yamashita, Shogo Aida, Masaki Sone, Kentaro Ichijo, Tomoki Nishioka, Kozo Kaibuchi, Yoshiiya Kawaguchi, Shinichiro Taya, Mikio Hoshino
EMBO J., 40, e105712 (2021).
Role of Drosophila YATA protein in the proper subcellular localization of COPI revealed by in vivo analysis
Maiko Saito, Minoru Nakayama, Kyota Fujita, Atsuko Uchida, Hiroyuki Yano, Satoshi Goto, Hitoshi Okazawa, Masaki Sone
Genes Genet. Syst., 95, 303-314 (2021).
Maiko Saito, Minoru Nakayama, Kyota Fujita, Atsuko Uchida, Hiroyuki Yano, Satoshi Goto, Hitoshi Okazawa, Masaki Sone
Genes Genet. Syst., 95, 303-314 (2021).
AUTS2 regulation of synapses for proper synaptic inputs and social communication.
Kei Hori, Kunihiko Yamashiro, Taku Nagai, Wei Shan, Saki F. Egusa, Kazumi Shimaoka, Hiroshi Kuniishi, Masayuki Sekiguchi, Yasuhiro Go, Shoji Tatsumoto, Mitsuyo Yamada, Reika Shiraishi, Kouta Kanno, Satoshi Miyashita, Asami Sakamoto, Manabu Abe, Kenji Sakimura, Masaki Sone, Kazuhiro Sohya, Hiroshi Kunugi, Keiji Wada, Mitsuhiko Yamada, Kiyofumi Yamada, Mikio Hoshino
iScience, 23, 101183 (2020).
Analysis of a cellular structure observed in the compound eyes of Drosophila white; yata mutants and white mutants.
Eri Arimoto*, Yutaro Kawashima*, Taein Choi, Mami Unagami, Shintaro Akiyama, Mizuki Tomizawa, Hiroyuki Yano, Emiko Suzuki, Masaki Sone
Biology Open, 9, bio047043 (2020).
(*: equal contribution)
Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model.
Koto Furotani, Keisuke Kamimura, Takaaki Yajima, Minoru Nakayama, Rena Enomoto, Takuya Tamura, Hitoshi Okazawa, Masaki Sone
PLoS One, 13, e0204048 (2018).
Koto Furotani, Keisuke Kamimura, Takaaki Yajima, Minoru Nakayama, Rena Enomoto, Takuya Tamura, Hitoshi Okazawa, Masaki Sone
PLoS One, 13, e0204048 (2018).
Characterization of the activity of beta-galactosidase from Escherichia coli and Drosophila melanogaster in fixed and non-fixed Drosophila tissues.
Mizuki Tomizawa*, Kohei Tsumaki*, Masaki Sone
Biochimie Open, 3, 1-7 (2016)
(*: equal contribution)
Mizuki Tomizawa*, Kohei Tsumaki*, Masaki Sone
Biochimie Open, 3, 1-7 (2016)
(*: equal contribution)
Systematic analysis of fly models with multiple drivers reveals different effects for Ataxin-1 and Huntingtin in neuron subtype-specific expression.
Risa Shiraishi, Takuya Tamura, Masaki Sone, Hitoshi Okazawa
PLoS One, 9, e116567 (2014).
Risa Shiraishi, Takuya Tamura, Masaki Sone, Hitoshi Okazawa
PLoS One, 9, e116567 (2014).
Systems biology abalysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.
Sam S Barclay, Takuya Tamura, Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Teppei Shimamura, Asuka Katsuta, Hiroki Shiwaku, Masaki Sone, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
Hum. Mol. Genet., 23, 1345-1364 (2014).
Sam S Barclay, Takuya Tamura, Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Teppei Shimamura, Asuka Katsuta, Hiroki Shiwaku, Masaki Sone, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
Hum. Mol. Genet., 23, 1345-1364 (2014).
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku, Masaki Sone, Chisato Yoshida, Masahisa Katsuno, Yoshinobu Eishi, Miho Murata, J. Paul Taylor, Erich E. Wanker, Kazuteru Kono, Satoshi Tashiro, Gen Sobue, Albert R. La Spada, Hitoshi Okazawa
Nature Commun., 4, 1816 (2013).
Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku, Masaki Sone, Chisato Yoshida, Masahisa Katsuno, Yoshinobu Eishi, Miho Murata, J. Paul Taylor, Erich E. Wanker, Kazuteru Kono, Satoshi Tashiro, Gen Sobue, Albert R. La Spada, Hitoshi Okazawa
Nature Commun., 4, 1816 (2013).
A restricted level of PQBP1 is needed for the best longevity of Drosophila.
Takuya Tamura, Masaki Sone, Yoko Nakamura, Teppei Shimamura, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
Neurobiol. Aging, 34, 356.e11-356.e20 (2013).
Takuya Tamura, Masaki Sone, Yoko Nakamura, Teppei Shimamura, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
Neurobiol. Aging, 34, 356.e11-356.e20 (2013).
Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.
Takuya Tamura, Masaki Sone, Takeshi Iwatsubo, Kazuhiko Tagawa, Erich E. Wanker, Hitoshi Okazawa
PLoS One, 6, e27408 (2011).
Takuya Tamura, Masaki Sone, Takeshi Iwatsubo, Kazuhiko Tagawa, Erich E. Wanker, Hitoshi Okazawa
PLoS One, 6, e27408 (2011).
Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning.
Takuya Tamura, Daisuke Horiuchi, Yi-Chung Chen, Masaki Sone, Tomoyuki Miyashita, Minoru Saitoe, Natsue Yoshimura, Ann-Shyn Chiang, Hitoshi Okazawa
J. Neurosci., 30, 14091-14101 (2010).
Takuya Tamura, Daisuke Horiuchi, Yi-Chung Chen, Masaki Sone, Tomoyuki Miyashita, Minoru Saitoe, Natsue Yoshimura, Ann-Shyn Chiang, Hitoshi Okazawa
J. Neurosci., 30, 14091-14101 (2010).
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
Hiroki Shiwaku, Natsue Yoshimura, Takuya Tamura, Masaki Sone, Soichi Ogishima, Kei Watase, Kazuhiko Tagawa, Hitoshi Okazawa
EMBO J., 29, 2446-2460 (2010).
Hiroki Shiwaku, Natsue Yoshimura, Takuya Tamura, Masaki Sone, Soichi Ogishima, Kei Watase, Kazuhiko Tagawa, Hitoshi Okazawa
EMBO J., 29, 2446-2460 (2010).
Mutant huntingtin impairs Ku70-mediated DNA repair.
Yasushi Enokido, Takuya Tamura, Hikaru Ito, Anup Arumughan, Akihiko Komuro, Hiroki Shiwaku, Masaki Sone, Raphaele Foulle, Hirohide Sawada, Hiroshi Ishiguro, Tetsuya Ono, Miho Murata, Ichiro Kanazawa, Nikolai Tomilin, Kazuhiko Tagawa, Erich E Wanker, Hitoshi Okazawa
J. Cell Biol., 189, 425-443 (2010).
Yasushi Enokido, Takuya Tamura, Hikaru Ito, Anup Arumughan, Akihiko Komuro, Hiroki Shiwaku, Masaki Sone, Raphaele Foulle, Hirohide Sawada, Hiroshi Ishiguro, Tetsuya Ono, Miho Murata, Ichiro Kanazawa, Nikolai Tomilin, Kazuhiko Tagawa, Erich E Wanker, Hitoshi Okazawa
J. Cell Biol., 189, 425-443 (2010).
Selected Publications of Masaki Sone, Ph.D. before 2009
Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
Masaki Sone^, Atsuko Uchida, Ayumi Komatsu, Emiko Suzuki, Ikue Ibuki, Megumi Asada, Hiroki Shiwaku, Takuya Tamura, Mikio Hoshino, Hitoshi Okazawa, Yo-ichi Nabeshima
PLoS One, 4, e4466 (2009). (^: corresponding author)
Masaki Sone^, Atsuko Uchida, Ayumi Komatsu, Emiko Suzuki, Ikue Ibuki, Megumi Asada, Hiroki Shiwaku, Takuya Tamura, Mikio Hoshino, Hitoshi Okazawa, Yo-ichi Nabeshima
PLoS One, 4, e4466 (2009). (^: corresponding author)
Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models.
Takuya Tamura, Masaki Sone, Mayumi Yamashita, Erich E. Wanker, Hitoshi Okazawa
PLoS One, 4, e4262 (2009).
Takuya Tamura, Masaki Sone, Mayumi Yamashita, Erich E. Wanker, Hitoshi Okazawa
PLoS One, 4, e4262 (2009).
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
Mikio Hoshino, Shoko Nakamura, Kiyoshi Mori, Takeshi Kawauchi, Mami Terao, Yoshiaki V. Nishimura, Akihisa Fukuda, Toshimitsu Fuse, Naoki Matsuo, Masaki Sone, Masahiko Watanabe, Haruhiko Bito, Toshio Terashima, Christopher V. E. Wright, Yoshiya Kawaguchi, Kazuwa Nakao, Yo-ichi Nabeshima
Neuron, 47, 201-213 (2005).
Mikio Hoshino, Shoko Nakamura, Kiyoshi Mori, Takeshi Kawauchi, Mami Terao, Yoshiaki V. Nishimura, Akihisa Fukuda, Toshimitsu Fuse, Naoki Matsuo, Masaki Sone, Masahiko Watanabe, Haruhiko Bito, Toshio Terashima, Christopher V. E. Wright, Yoshiya Kawaguchi, Kazuwa Nakao, Yo-ichi Nabeshima
Neuron, 47, 201-213 (2005).
Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration.
Masato Yoshizawa, Masaki Sone&, Takeshi Kawauchi&, Yoshiaki V. Nishimura, Mami Terao, Kaori Chihama, Yo-ichi Nabeshima, Mikio Hoshino
J. Neurosci., 25, 4406-4419 (2005)
(&: equal contribution).
Masato Yoshizawa, Masaki Sone&, Takeshi Kawauchi&, Yoshiaki V. Nishimura, Mami Terao, Kaori Chihama, Yo-ichi Nabeshima, Mikio Hoshino
J. Neurosci., 25, 4406-4419 (2005)
(&: equal contribution).
Dynamic and coordinated expression profile of Dbl-family guanine nucleotide exchange factors in the developing mouse brain.
Masato Yoshizawa, Masaki Sone, Naoki Matsuo, Takahiro Nagase, Osamu Ohara,
Yo-ichi Nabeshima, Mikio Hoshino
Gene Expr. Pat., 3, 375-381 (2003).
Masato Yoshizawa, Masaki Sone, Naoki Matsuo, Takahiro Nagase, Osamu Ohara,
Yo-ichi Nabeshima, Mikio Hoshino
Gene Expr. Pat., 3, 375-381 (2003).
Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain.
Masato Yoshizawa, Mikio Hoshino, Masaki Sone, Yo-ichi Nabeshima
Mech. Dev., 113, 65-68 (2002).
Masato Yoshizawa, Mikio Hoshino, Masaki Sone, Yo-ichi Nabeshima
Mech. Dev., 113, 65-68 (2002).
Synaptic development is controlled in the periactive zones of Drosophila synapses.
Masaki Sone, Emiko Suzuki, Mikio Hoshino, Dongmei Hou, Hiroshi Kuromi, Masaki Fukata, Shinya Kuroda, Kozo Kaibuchi, Yo-ichi Nabeshima, Chihiro Hama
Development, 127, 4157-4168 (2000).
Masaki Sone, Emiko Suzuki, Mikio Hoshino, Dongmei Hou, Hiroshi Kuromi, Masaki Fukata, Shinya Kuroda, Kozo Kaibuchi, Yo-ichi Nabeshima, Chihiro Hama
Development, 127, 4157-4168 (2000).
The Drosophila Trio plays an essential role in patterning of axons by regulating their directional extension.
Takeshi Awasaki, Mai Saito, Masaki Sone, Emiko Suzuki, Ryoko Sakai, Kei Ito, Chihiro Hama
Neuron, 26, 119-131 (2000).
Takeshi Awasaki, Mai Saito, Masaki Sone, Emiko Suzuki, Ryoko Sakai, Kei Ito, Chihiro Hama
Neuron, 26, 119-131 (2000).
Gal4/USA-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways.
Katsuhiko Tabuchi, Kazunobu Sawamoto, Emiko Suzuki, Koichi Ozaki, Masaki Sone, Chihiro Hama, Takako Tanifuji-Morimoto, Yoshihiro Yuasa, Yoshihiro Yoshihara, Akinao Nose, Hideyuki Okano
J. Neurosci. Res., 59, 94-99 (2000).
Katsuhiko Tabuchi, Kazunobu Sawamoto, Emiko Suzuki, Koichi Ozaki, Masaki Sone, Chihiro Hama, Takako Tanifuji-Morimoto, Yoshihiro Yuasa, Yoshihiro Yoshihara, Akinao Nose, Hideyuki Okano
J. Neurosci. Res., 59, 94-99 (2000).
Identification of the stef gene that encodes a novel guanine-nucleotide exchange factor specific for Rac1.
Mikio Hoshino, Masaki Sone, Masaki Fukata, Shinya Kuroda, Kozo Kaibuchi, Yo-ichi Nabeshima, Chihiro Hama
J. Biol. Chem., 274, 17837-17844 (1999).
Mikio Hoshino, Masaki Sone, Masaki Fukata, Shinya Kuroda, Kozo Kaibuchi, Yo-ichi Nabeshima, Chihiro Hama
J. Biol. Chem., 274, 17837-17844 (1999).
Neural expression of Hikaru genki protein during embryonic and larval development of Drosophila melanogaster.
Mikio Hoshino, Emiko Suzuki, Tadashi Miyake, Masaki Sone, Akira Komatsu, Yo-ichi Nabeshima, Chihiro Hama
Dev. Genes Evol., 209, 1-9 (1999).
Mikio Hoshino, Emiko Suzuki, Tadashi Miyake, Masaki Sone, Akira Komatsu, Yo-ichi Nabeshima, Chihiro Hama
Dev. Genes Evol., 209, 1-9 (1999).
Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers.
Masaki Sone, Mikio Hoshino, Emiko Suzuki, Shinya Kuroda, Kozo Kaibuchi, Hideki Nakagoshi, Kaoru Saigo, Yo-ichi Nabeshima, Chihiro Hama
Science, 275, 543-547 (1997).
Masaki Sone, Mikio Hoshino, Emiko Suzuki, Shinya Kuroda, Kozo Kaibuchi, Hideki Nakagoshi, Kaoru Saigo, Yo-ichi Nabeshima, Chihiro Hama
Science, 275, 543-547 (1997).
Mechanism of induction of Bar-like eye malformation by transient overexpression of Bar homeobox genes in Drosophila melanogaster.
Masaki Sone&, Tetsuya Kojima&, Tatsuo Michiue&, Kaoru Saigo
Genetica, 88, 85-91 (1993) (& : equal contribution).
Masaki Sone&, Tetsuya Kojima&, Tatsuo Michiue&, Kaoru Saigo
Genetica, 88, 85-91 (1993) (& : equal contribution).
Identification of a different-type homeobox gene BarHI, possibly causing Bar (B) and Om(1D) mutations in Drosophila.
Tetsuya Kojima, Satoshi Ishimaru, Shin-ichi Higashijima, Eiji Takayama, Hiroshi Akimaru, Masaki Sone, Yasufumi Emori, Kaoru Saigo
Proc. Natl. Acad. Sci. USA, 88, 4343-4347 (1991).
Tetsuya Kojima, Satoshi Ishimaru, Shin-ichi Higashijima, Eiji Takayama, Hiroshi Akimaru, Masaki Sone, Yasufumi Emori, Kaoru Saigo
Proc. Natl. Acad. Sci. USA, 88, 4343-4347 (1991).