Tsukada Laboratory,
Department of Biomolecular Science,
Faculty of Science,
Toho University

Miyama2-2-1, Funabashi,
Chiba, 274-8510 Japan

Tsukada Laboratory

Whispering of ‘Structure’: Decode the function behind the ‘Structure’

Living creatures have acquired beautiful structures through the process of evolution. The structure endows not only biophysical properties but also functional properties to tissues. There are still lots of undiscovered functions behind the structure. In my laboratory, we are studying the mechanisms of tissue formation, breakdown, and remodeling using Japanese eel and rodents (mouse and rat).

Graduate Students

We are looking for graduate students who want to study with us!

Contact: takehirotsukada(at)sci.toho-u.ac.jp


2018/4/4 New member!
2018/4/3 Tsukada: Publication in an international journal, Scientific Report (Title: Isolation and characterisation of CD9-positive pituitary adult stem/progenitor cells in rats). This paper found that stem/progenitor cells in rat anterior pituitary express cell surface marker CD9 and we successfully isolated stem/progenitor cells. Our finding will accelerate stem cell research in the pituitary gland and also will contribute to understanding of disease mechanism in the pituitary gland. This is collaborative work with Kyorin University, Meiji University, and Jichi Medical University.
2017/12/25 Tsukada: Publication in an international journal, Cell and Tissue Research (Title: TGFβ signaling reinforces pericyte properties of the non-endocrine mouse pituitary cell line TtT/GF). This paper investigated property of TtT/GF cell derived from mouse pituitary tumor. We found that TGFβ (cytokine) changes property of TtT/GF cells toward pericyte (mural cell of microvessel). Microvessel formation is very important to maintain pituitary function. Our finding revealed a molecular mechanism of vessel formation in the pituitary. This is collaborative work with Meiji University, Jichi Medical University, and Kyorin University.
2017/12/16 Tsukada&Yokota: Present a paper in 8th Peptide and Hormone Research Meeting (Nagahama, Shiga), entitled ‘Deciphering brain functions of C-type natriuretic peptide using Japanese eel’.
2017/12/13 Tsukada: Publication in an international journal, Zoological Letters (Title: A sodium binding system alleviates acute salt stress during seawater acclimation in eels). This paper shows existence of sodium binding molecule in Japanese eel, Anguilla japonica. Salt (NaCl) is an important substance for animal and body salt balance is tightly regulated by many osmoregulatory systems. Our finding added a new salt regulation system to the known systems. This is collaborative work with Atmosphere and Ocean Research Institute, The University of Tokyo.